Title
On-line monitoring of electrolytes in hemodialysis: On the road towards individualizing treatment
Author
Sharma, M.K.
Wieringa, F.P.
Frijns, A.J.H.
Kooman, J.P.
Publication year
2016
Abstract
Introduction: End-stage renal disease (ESRD) patients depend on dialysis for removal of toxic waste products, fluid overload relief and maintenance of electrolyte balance. Dialysis prolongs millions of lives. To some extent, ESRD has become a manageable disease with a steadily growing dialysis population of increasing average age and associated comorbidity. During 7 decades many technical refinements have been developed e.g. sodium profiling, blood volume, ultrafiltration variation based on blood pressure measurement, urea kinetics etc. Despite its large potentials, in-line electrolyte monitoring lags behind in dialysis treatment. Areas covered: In this paper, we review the state of technologies available for in-line monitoring of the electrolytes sodium, potassium and calcium during hemodialysis. Expert commentary: We concluded that individual optimization of dialysate composition should be able to improve hard medical outcomes, but practical clinical implementation stands/falls with reliable and affordable in-line ion-selective sensing technology. Optical ion-selective microsensors and microsystems form a promising pathway for individualizing the dialysis treatment. © 2016 The Author(s)
Subject
Nano Technology
OPT - Optics
TS - Technical Sciences
High Tech Systems & Materials
Health
Industrial Innovation
Conductivity
Dialysis
Dialysis dose
Electrolyte balance
Optical sensor
Urea monitors
Blood pressure
Electric conductivity
Electrolytes
Hemodialyzers
Metabolism
Microfluidics
Microsystems
Optical sensors
Toxic materials
Voltage measurement
Blood volumes
Co morbidities
Dialysates
End-stage renal disease patients
In-line monitoring
Online monitoring
Selective sensing
Waste products
To reference this document use:
http://resolver.tudelft.nl/uuid:4c617fe3-4439-417c-bb47-cc573b32cdd1
TNO identifier
573291
Publisher
Taylor and Francis
ISSN
1743-4440
Source
Expert Review of Medical Devices, 13 (10), 933-943
Bibliographical note
Funding Details: NT12.02, Nierstichting
Document type
article