Systems biology, connectivity and the future of medicine

Title

Systems biology, connectivity and the future of medicine

 Author

van der Greef, J.
TNO Kwaliteit van Leven

Publication year

2005

 Abstract

The concept of systems-based strategies in medicine is emerging, with systems pathology guiding an understanding of the multidimensional aspects of disease system fingerprints and systems pharmacology providing insight into dynamic system responses upon (multiple) drug perturbations. Knowledge of the changes of system characteristics during disease progression creates a framework for the design of novel combinatorial treatment strategies. Such a systems-based, combinatorial-therapies approach readdresses the value of the synergistic actions of components of treatments based on natural products and highlights new methodology to study multidimensional intervention via reversed-pharmacology. © IEEE, 2005.

 Subject

Biology
Analytical research
Disease progression
Disease system fingerprints
Diseases
Drug perturbations
Drugs
Medicine
Patient treatment
Reversed-pharmacology
Systems biology
Systems pathology
Systems pharmacology
Systems-based combinatorial-therapies approach
Biology
Diseases
Drug therapy
Pathology
Pharmacokinetics
Disease system fingerprints
Pharmacology
Systems biology
Drug products
amlodipine plus atorvastatin
berberine
biological marker
fluticasone propionate plus salmeterol
ginseng extract
glibenclamide plus metformin
article
asthma
bioinformatics
biostatistics
cardiovascular disease
clinical protocol
disease course
drug design
drug industry
drug research
human
hypercholesterolemia
in vivo study
medicine
metabolic syndrome X
methodology
molecular biology
non insulin dependent diabetes mellitus
nonhuman
quality control
quality of life
Cell Physiology
Drug Design
Models, Biological
Pharmaceutical Preparations
Pharmacology
Pharmacology, Clinical
Systems Biology
Panax ginseng

 To reference this document use:

http://resolver.tudelft.nl/uuid:4c2bc507-d774-467d-bc40-96e924e4ea86

 DOI

https://doi.org/10.1049/ip-syb:20050034

 TNO identifier

238849

 ISSN

1741-2471

 Source

IEE Proceedings Systems Biology, 152 (4), 174-178

 Document type

article
Files
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