Print Email Facebook Twitter Vitamin B6 status of women suffering from premenstrual syndrome Title Vitamin B6 status of women suffering from premenstrual syndrome Author van den Berg, H. Louwerse, E.S. Bruinse, H.W. Thissen, J.T.N.M. Schrijver, J. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1986 Abstract The vitamin B6 status of women suffering from premenstrual symptoms (PMS, n = 19) and a group of matched controls (n = 19) has been investigated. The women volunteering in the study were selected on strictly defined criteria. Several biochemical parameters of the metabolism of vitamin B6 and tryptophan were studied in blood and urine samples during a full menstrual cycle. No significant differences in plasma pyridoxal and pyridoxal-5'-phosphate (PLP) concentrations, the holo and total EGOT activity, the erythrocyte pyridoxine kinase activity and the urinary 4-pyridoxic acid excretion between the two groups were observed. The excretion of the tryptophan metabolites xanthurenic acid (XA) and 8-methyl-xanthurenic acid (MXA), before as well as after an oral tryptophan load, tended to be higher for the PMS group. Each of the groups showed a significant cyclic variation during the menstrual cycle in the holo and total EGOT activities and in the excretion of XA and MXA before as well as after an oral tryptophan load. It is concluded that PMS is not related to a 'cyclic' vitamin B6 status. The slight differences observed for tryptophan metabolism between the PMS and the control group deserve further study. Chemicals/CAS: pyridoxine, 12001-77-3, 58-56-0, 65-23-6, 8059-24-3; tryptophan, 6912-86-3, 73-22-3; aspartate aminotransferase, 9000-97-9; pyridoxal 5 phosphate, 54-47-7; pyridoxal kinase, 9026-42-0; pyridoxal, 65-22-5, 66-72-8; pyridoxic acid, 82-82-6; xanthurenic acid 8 methyl ether, 2929-14-8; xanthurenic acid, 59-00-7; Aspartate Aminotransferases, EC 184.108.40.206; Pyridoxal Kinase, EC 220.127.116.11; Pyridoxal Phosphate, 54-47-7; Pyridoxal, 66-72-8; Pyridoxic Acid, 82-82-6; Pyridoxine, 65-23-6; Tryptophan, 73-22-3; Xanthurenates; xanthurenic acid 8-methyl ether, 2929-14-8; xanthurenic acid, 59-00-7 Subject PyridoxineTryptophanAspartate aminotransferasePyridoxalPyridoxal 5 phosphatePyridoxal kinasePyridoxic acidXanthurenic acidXanthurenic acid 8 methyl etherXanthurenic acid 8-methyl etherAdultClinical articleControlled studyFemale genital systemHumanMenstrual cycleMetabolismNetherlandsPremenstrual syndromePriority journalTherapyAdolescentArticleBloodEnzymologyErythrocyteFemaleUrineAdolescentAdultAspartate AminotransferasesErythrocytesFemaleHumanMenstrual CycleMiddle AgePremenstrual SyndromePyridoxalPyridoxal KinasePyridoxal PhosphatePyridoxic AcidPyridoxineTryptophanXanthurenates To reference this document use: http://resolver.tudelft.nl/uuid:4be9d3fb-dc69-4066-b59d-83306fbb76e2 TNO identifier 230253 Source Human Nutrition: Clinical Nutrition, 40 (6), 441-450 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.