Print Email Facebook Twitter The effects of 4-aminopyridine on cognitive function in patients with multiple sclerose: A pilot study Title The effects of 4-aminopyridine on cognitive function in patients with multiple sclerose: A pilot study Author Smits, R.C.F. Emmen, H.H. Bertelmans, F.W. Kulig, B.M. van Loenen, A.C. Polman, C.H. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1994 Abstract 4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could not demonstrate significant effects of 4-AP on cognitive function. Chemicals/CAS: 4-Aminopyridine, 504-24-5; Placebos Subject 4 AminopyridineClinical articleClinical trialCognitionControlled clinical trialControlled studyCrossover procedureDouble blind procedureHearing testMultiple sclerosisNeuropsychological testOral drug administrationRandomized controlled trialTask performanceVerbal memoryVisual memory4-AminopyridineAdultAgedCognition DisordersDouble-Blind MethodFemaleHumansMaleMiddle AgedMultiple SclerosisNeuropsychological TestsPilot ProjectsPlacebos To reference this document use: http://resolver.tudelft.nl/uuid:4b2644c2-694c-459d-95af-ce9eb032bfbc TNO identifier 36538 Source Neurology, 44, 1701-1705 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.