Print Email Facebook Twitter Fluid loss does not explain coagulation activation during air travel Title Fluid loss does not explain coagulation activation during air travel Author Schreijer, A.J.M. Cannegieter, S.C. Caramella, M. Meijers, J.C.M. Krediet, R.T. Simons, M. Rosendaal, F.R. TNO Defensie en Veiligheid Publication year 2008 Abstract The mechanism of air travel-related venous thrombosis is unclear. Although immobility plays a pivotal role, other factors such as fluid loss may contribute. We investigated whether fluid loss occurred more in individuals with coagulation activation after air travel than in subjects without. As a secondary aim, we investigated whether fluid loss per se occurred during air travel. In this crossover study, 71 healthy volunteers were exposed to eight hours of air travel, eight hours immobilization in a cinema, and a daily-life control situation. Markers of fluid loss (haematocrit, serum osmolality and albumin) and of coagulation activation were measured before and after each exposure. The study included 11 volunteers with and 55 volunteers without coagulation activation during the flight. The change in parameters of fluid loss was not different in volunteers with an activated clotting system from those without (difference between groups in haematocrit: -0.6%, 95% confidence interval [CI]: -1.9 to 0.6). On a group level, mean haematocrit values decreased during all three exposures. However, in some individuals it increased, which occurred in more participants during the flight (34%; 95% CI 22 to 46) than during the daily-life situation (19%; 95% CI 10 to 28). These findings do not support the hypothesis that fluid loss contributes to thrombus formation during air travel. © 2008 Schattauer GmbH. Subject BiologyAir travelDehydrationFluid lossHypercoagulabilityVenous thrombosisSerum albuminAviationBlood clottingDaily life activityDehydrationFemaleHematocritHumanImmobilizationMalePriority journalSerum osmolalityActivities of Daily LivingAdultAircraftAntithrombin IIIBlood CoagulationCross-Over StudiesDehydrationDrinkingFibrin Fibrinogen Degradation ProductsHematocritImmobilizationMaleOsmolar ConcentrationPeptide FragmentsPeptide HydrolasesProthrombinRisk FactorsSerum AlbuminTravelVenous ThrombosisWater-Electrolyte BalanceSeasicknessMotion sicknessDrugs To reference this document use: http://resolver.tudelft.nl/uuid:4a6e4647-719b-4bee-b7d5-aa12f3a9de69 DOI https://doi.org/10.1160/th07-11-0681 TNO identifier 23561 Source Thrombosis and Haemostasis, 99 (6), 1053-1059 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.