Title
Some effects of an ACTH 4-9 analog (Org 2766) on human performance
Author
Gaillard, A.W.K.
Varey, C.A.
Instituut voor Zintuigfysiologie TNO
Publication year
1979
Abstract
The effects (on human beings) of the ACTH analog Org 2766 were investigated for a range of performance tests: complicated serial reaction task, running memory span, verbal learning and non-verbal mental ability tests (closure flexibility and non-verbal abstraction). Subjective ratings on feeling were taken and heart rate was measured. Only the 30-min reaction task produced significant drug effects. In this task, performance tends to deteriorate as a function of time on task. During the test period there is a gradual increase in the number of lapses in performance due to moments of inattention. This deterioration is counteracted by the ACTH 4-9 analog, a result also found in a previous study using ACTH 4-10 (Org 0163). Thus ACTH fragments which are devoid of endocrine effects seem to have a beneficial effect on goal-directed motivation oriented on the requirements of the task. Chemicals/CAS: 2 amino 4 (methylsulfonyl)butyrylglutamylhistidylphenylalanyl dextro lysylphenylalanine, 50913-82-1; corticotropin[4-10], 4037-01-8; Corticotropin, 9002-60-2
Subject
2 amino 4 (methylsulfonyl)butyrylglutamylhistidylphenylalanyl dextro lysylphenylalanine
Corticotropin derivative
Corticotropin[4-10]
Org oi63
Placebo
Unclassified drug
Central nervous system
Corticotropin[4-9]
Drug efficacy
Heart
Human cell
Normal human
Oral drug administration
Performance
Psychological aspect
Therapy
Touch
Corticotropin
Emotions
Female
Heart Rate
Human
Male
Memory
Motivation
Psychological Tests
Reaction Time
Time Factors
Verbal Learning
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DOI
https://doi.org/10.1016/0031-9384(79)90126-4
TNO identifier
5092
Source
Physiological Behaviour, 23 (1), 79-84
Document type
article