Title
Non-invasive measurement of brain damage in a primate model of multiple sclerosis
Author
'T Hart, B.A.
Vogels, J.
Bauer, J.
Brok, H.P.M.
Blezer, E.
TNO Voeding
Publication year
2004
Abstract
Early recognition of whether a product has potential as a new therapy for treating multiple sclerosis (MS) relies upon the quality of the animal models used in the preclinical trials. The promising effects of new treatments in rodent models of experimental autoimmune encephalomyelitis (EAE) have rarely been reproduced in patients suffering from MS. EAE in outbred marmoset monkeys, Callithrix jacchus, is a valid new model, and might provide an experimental link between EAE in rodent models and human MS. Using magnetic resonance imaging techniques similar to those used in patients suffering from MS pathological abnormalities in the brain, white matter of the animal can be visualized and quantified. Moreover, NMR spectroscopy, in combination with pattern recognition, offers an advanced uroscopic technique for the identification of biomarkers of inflammatory demyelination.
Subject
Biology Health
Analytical research
myelin
allergic encephalomyelitis
brain injury
chemometric analysis
demyelination
diagnostic imaging
human
immunopathology
marmoset
multiple sclerosis
neurologic disease
neuropathology
non invasive measurement
nonhuman
nuclear magnetic resonance imaging
nuclear magnetic resonance spectroscopy
pattern recognition
positron emission tomography
proton nuclear magnetic resonance
review
urinalysis
white matter
X ray analysis
Animals
Animals, Outbred Strains
Antigens, CD
Biological Markers
Brain
Callithrix
CD4-Positive T-Lymphocytes
Chronic Disease
Demyelinating Diseases
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental
Genes, MHC Class II
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Mice
Multiple Sclerosis
Myelin Basic Proteins
Myelin-Associated Glycoprotein
T-Lymphocytes, Cytotoxic
Th2 Cells
Animalia
Callithrix
Callithrix jacchus
marmosets
Primates
Rodentia
To reference this document use:
http://resolver.tudelft.nl/uuid:4826f84e-36af-4934-aa8b-ca72fb0d27a1
DOI
https://doi.org/10.1016/j.molmed.2003.12.008
TNO identifier
237600
ISSN
1471-4914
Source
Trends in Molecular Medicine, 10 (2), 85-91
Document type
article