Print Email Facebook Twitter Non-invasive measurement of brain damage in a primate model of multiple sclerosis Title Non-invasive measurement of brain damage in a primate model of multiple sclerosis Author 'T Hart, B.A. Vogels, J. Bauer, J. Brok, H.P.M. Blezer, E. TNO Voeding Publication year 2004 Abstract Early recognition of whether a product has potential as a new therapy for treating multiple sclerosis (MS) relies upon the quality of the animal models used in the preclinical trials. The promising effects of new treatments in rodent models of experimental autoimmune encephalomyelitis (EAE) have rarely been reproduced in patients suffering from MS. EAE in outbred marmoset monkeys, Callithrix jacchus, is a valid new model, and might provide an experimental link between EAE in rodent models and human MS. Using magnetic resonance imaging techniques similar to those used in patients suffering from MS pathological abnormalities in the brain, white matter of the animal can be visualized and quantified. Moreover, NMR spectroscopy, in combination with pattern recognition, offers an advanced uroscopic technique for the identification of biomarkers of inflammatory demyelination. Subject Biology HealthAnalytical researchmyelinallergic encephalomyelitisbrain injurychemometric analysisdemyelinationdiagnostic imaginghumanimmunopathologymarmosetmultiple sclerosisneurologic diseaseneuropathologynon invasive measurementnonhumannuclear magnetic resonance imagingnuclear magnetic resonance spectroscopypattern recognitionpositron emission tomographyproton nuclear magnetic resonancereviewurinalysiswhite matterX ray analysisAnimalsAnimals, Outbred StrainsAntigens, CDBiological MarkersBrainCallithrixCD4-Positive T-LymphocytesChronic DiseaseDemyelinating DiseasesDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalGenes, MHC Class IIHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMiceMultiple SclerosisMyelin Basic ProteinsMyelin-Associated GlycoproteinT-Lymphocytes, CytotoxicTh2 CellsAnimaliaCallithrixCallithrix jacchusmarmosetsPrimatesRodentia To reference this document use: http://resolver.tudelft.nl/uuid:4826f84e-36af-4934-aa8b-ca72fb0d27a1 DOI https://doi.org/10.1016/j.molmed.2003.12.008 TNO identifier 237600 ISSN 1471-4914 Source Trends in Molecular Medicine, 10 (2), 85-91 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.