Title
Evidence of the regulatory effect of Ginkgo biloba extract on skin blood flow and study of its effects on urinary metabolites in healthy humans
Author
Boelsma, E.
Lamers, R.-J.A.N.
Hendriks, H.F.J.
van Nesselrooij, J.H.J.
Roza, L.
TNO Voeding
Publication year
2004
Abstract
Ginkgo biloba extract has been advocated for the improvement of blood circulation in circulatory disorders. This study investigated the effect of the Gingko biloba extract EGb 761 on skin blood flow in healthy volunteers and accompanying changes in urinary metabolites. Twenty-seven healthy middle-aged subjects participated in a randomized, double-blind, placebo-controlled, crossover study. Subjects received 240 mg/d EGb 761 or placebo for periods of 3 weeks. Skin blood flow was measured on the forefoot using laser Doppler flowmetry and changes in urinary metabolites were identified by a combination of nuclear magnetic resonance (NMR) spectroscopy and multivariate data analysis (MVDA). These measurements were performed on 24-h urine samples collected at the end of the intervention periods. Following EGb 761 treatment, overall mean skin blood flow was significantly reduced as compared with placebo. Remarkably, the change of skin blood flow after EGb 761 intervention was proportionally related to blood flow after placebo treatment: subjects showed either an increased, decreased or unaltered skin blood flow. NMR/MDVA analyses showed that urinary metabolic patterns differed depending on the change in baseline blood flow after treatment with EGb 761. The present findings substantiate that EGb 761 has a multi-directional modulating action on blood flow in healthy subjects and support findings of a vasoregulatory role of this extract. Moreover, the results indicate that metabolic fingerprinting provides a powerful means to identify biochemical markers that are associated with functional changes.
Subject
Biology
Physiological Sciences
Circulation disorders
Ginkgo biloba extract
Ginkgoaceae
Metabolic fingerprinting
NMR spectroscopy
Ginkgo biloba extract
placebo
tavonin
adult
aged
article
clinical article
clinical trial
controlled clinical trial
controlled study
crossover procedure
double blind procedure
drug effect
female
forefoot
Ginkgo biloba
human
ischemia
laser Doppler flowmetry
male
multivariate analysis
nuclear magnetic resonance spectroscopy
randomized controlled trial
skin blood flow
urinalysis
Aged
Blood Flow Velocity
Cross-Over Studies
Double-Blind Method
Female
Ginkgo biloba
Humans
Laser-Doppler Flowmetry
Male
Middle Aged
Phytotherapy
Plant Extracts
Pulsatile Flow
Skin
Urinalysis
Gingko biloba
Ginkgo biloba
Ginkgoaceae
To reference this document use:
http://resolver.tudelft.nl/uuid:47d18641-fde5-40e3-8bc8-5378e5b3346a
DOI
https://doi.org/10.1055/s-2004-832646
TNO identifier
238074
ISSN
0032-0943
Source
Planta Medica, 70 (11), 1052-1057
Document type
article