Title
The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST
Author
Verhoeckx, K.
Bogh, K.L.
Dupont, D.
Egger, L.
Gadermaier, G.
Larre, C.
Mackie, A.
Menard, O.
Adel-Patient, K.
Picariello, G.
Portmann, R.
Smit, J.
Turner, P.
Untersmayr, E.
Epstein, M.M.
Publication year
2019
Abstract
The current allergenicity assessment of novel proteins is based on the EFSA GMO guidance. Recently, EFSA launched a new guidance document on allergenicity assessment of GM plants (2017). This document describes, amongst other topics, the new scientific and regulatory developments on in vitro protein digestibility tests. The EFSA GMO Panel stated that for in vitro protein digestibility tests, additional investigations are needed before any additional recommendation in the form of guidance can be provided. To this end, an interim phase is considered necessary to evaluate the revisions to the in vitro gastrointestinal digestion test, proposed by EFSA. This prompted the establishment of a joint workshop through two COST Action networks: COST Action ImpARAS and COST Acton INFOGEST. In 2017, a workshop was organised to discuss the relevance of digestion in allergenicity risk assessment and how to potentially improve the current methods and readouts. The outcome of the workshop is that there is no rationale for a clear readout that is predictive for allergenicity and we suggest to omit the digestion test from the allergenicity assessment strategy for now, and put an effort into filling the knowledge gaps as summarized in this paper first. © 2019 The Authors. Chemicals / CAS protein, 67254-75-5
Subject
Allergenicity risk assessment
Food allergy
Food digestion
In vitro protein digestibility tests
Novel proteins
Immunoglobulin E antibody
Intestine enzyme
Protein
Allergenicity
Allergic reaction
Biological activity
Brush border
Digestion
Human
Immune response
Immunogenicity
In vitro study
Risk assessment
Sensitization
Workshop
To reference this document use:
http://resolver.tudelft.nl/uuid:46fbf070-7fe5-49b8-93cf-896192a11ce4
DOI
https://doi.org/10.1016/j.fct.2019.04.052
TNO identifier
867238
Source
Food and Chemical Toxicology, 129 (129), 405-423
Document type
article