CD36 is important for adipocyte recruitment and affects lipolysis
van Klinken, J.B.
van Diepen, J.A.
van den Berg, S.A.
van Dijk, K.W.
van Harmelen, V.
Objective: The scavenger receptor CD36 facilitates the cellular uptake of long-chain fatty acids. As CD36-deficiency attenuates the development of high fat diet (HFD)-induced obesity, the role of CD36-deficiency in preadipocyte recruitment and adipocyte function was set out to characterize. Design and methods: Fat cell size and number were determined in gonadal, visceral, and subcutaneous adipose tissue of CD36(-/-) and WT mice after 6 weeks on HFD. Basal lipolysis and insulin-inhibited lipolysis were investigated in gonadal adipose tissue. Results: CD36(-/-) mice showed a reduction in adipocyte size in all fat pads. Gonadal adipose tissue also showed a lower total number of adipocytes because of a lower number of very small adipocytes (diameter
To reference this document use:
Food and Nutrition
MHR - Metabolic Health Research
EELS - Earth, Environmental and Life Sciences
Obesity (Silver Spring), 21 (21), 2037-2045