Title
CD36 is important for adipocyte recruitment and affects lipolysis
Author
Vroegrijk, I.O.
van Klinken, J.B.
van Diepen, J.A.
van den Berg, S.A.
Febbraio, M.
Steinbusch, L.K.
Glatz, J.F.
Havekes, L.M.
Voshol, P.J.
Rensen, P.C.
van Dijk, K.W.
van Harmelen, V.
Publication year
2013
Abstract
Objective: The scavenger receptor CD36 facilitates the cellular uptake of long-chain fatty acids. As CD36-deficiency attenuates the development of high fat diet (HFD)-induced obesity, the role of CD36-deficiency in preadipocyte recruitment and adipocyte function was set out to characterize. Design and methods: Fat cell size and number were determined in gonadal, visceral, and subcutaneous adipose tissue of CD36(-/-) and WT mice after 6 weeks on HFD. Basal lipolysis and insulin-inhibited lipolysis were investigated in gonadal adipose tissue. Results: CD36(-/-) mice showed a reduction in adipocyte size in all fat pads. Gonadal adipose tissue also showed a lower total number of adipocytes because of a lower number of very small adipocytes (diameter
Subject
Health
Food and Nutrition
Healthy Living
Life
MHR - Metabolic Health Research
EELS - Earth, Environmental and Life Sciences
To reference this document use:
http://resolver.tudelft.nl/uuid:456007ab-13ce-45f4-9476-1fe7189eb0ef
DOI
https://doi.org/10.1002/oby.20354
TNO identifier
525804
Source
Obesity (Silver Spring), 21 (21), 2037-2045
Document type
article