Print Email Facebook Twitter A prospective, double-blind, split-subject study on local skin reactions after administration of human menopausal gonadotrophin preparations to healthy female volunteers Title A prospective, double-blind, split-subject study on local skin reactions after administration of human menopausal gonadotrophin preparations to healthy female volunteers Author Odink, J. Zuiderwijk, P.B.M. Schoen, E.D. Gan, R.A. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1995 Abstract This study was designed to investigate local reactions after the intracutaneous (i.c.) administration of two human menopausal gonadotrophin preparations. For this purpose, 20 healthy female volunteers received six i.c. injections simultaneously, viz. three different batches of both Humegon (Organon, Oss, The Netherlands) and Pergonal (Serono, Geneva, Switzerland) at six different sites on their bodies. Local pain, induration and erythema were registered at 2, 4 and 24 h after administration. No pain was observed. At 4 h after administration, Pergonal-treated sites showed more induration (P = 0.008) and greater surfaces of erythema (P < 0.001) than Humegon-treated sites. Batches of Pergonal showed variation in the surface of erythema induced (P < 0.001), indicating heterogeneity of the batches tested. Subject BiologyAdultDouble-Blind MethodDrug EruptionsFemaleHumansInjections, IntradermalMenotropinsOvulation InductionProspective StudiesTime FactorsErythemaIndurationPainSkin reaction To reference this document use: http://resolver.tudelft.nl/uuid:45402ff3-c3db-4889-90c5-0269595a76d1 TNO identifier 51987 ISSN 0268-1161 Source Human Reproduction, 10 (5), 1045-1047 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.