Title
A prospective, double-blind, split-subject study on local skin reactions after administration of human menopausal gonadotrophin preparations to healthy female volunteers
Author
Odink, J.
Zuiderwijk, P.B.M.
Schoen, E.D.
Gan, R.A.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
1995
Abstract
This study was designed to investigate local reactions after the intracutaneous (i.c.) administration of two human menopausal gonadotrophin preparations. For this purpose, 20 healthy female volunteers received six i.c. injections simultaneously, viz. three different batches of both Humegon (Organon, Oss, The Netherlands) and Pergonal (Serono, Geneva, Switzerland) at six different sites on their bodies. Local pain, induration and erythema were registered at 2, 4 and 24 h after administration. No pain was observed. At 4 h after administration, Pergonal-treated sites showed more induration (P = 0.008) and greater surfaces of erythema (P < 0.001) than Humegon-treated sites. Batches of Pergonal showed variation in the surface of erythema induced (P < 0.001), indicating heterogeneity of the batches tested.
Subject
Biology
Adult
Double-Blind Method
Drug Eruptions
Female
Humans
Injections, Intradermal
Menotropins
Ovulation Induction
Prospective Studies
Time Factors
Erythema
Induration
Pain
Skin reaction
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http://resolver.tudelft.nl/uuid:45402ff3-c3db-4889-90c5-0269595a76d1
TNO identifier
51987
ISSN
0268-1161
Source
Human Reproduction, 10 (5), 1045-1047
Document type
article