Title
Effect of body fat distribution on the transcription response to dietary fat interventions
Author
TNO Kwaliteit van Leven
Radonjic, M.
van Erk, M.J.
Pasman, W.J.
Wortelboer, H.M.
Hendriks, H.F.J.
van Ommen, B.
Publication year
2009
Abstract
Combination of decreased energy expenditure and increased food intake results in fat accumulation either in the abdominal site (upper body obesity, UBO) or on the hips (lower body obesity, LBO). In this study, we used microarray gene expression profiling of adipose tissue biopsies to investigate the effect of body fat distribution on the physiological response to two dietary fat interventions. Mildly obese UBO and LBO male subjects (n = 12, waist-to-hip ratio range 0.93-1.12) were subjected to consumption of diets containing predominantly either long-chain fatty acids (PUFA) or medium-chain fatty acids (MCT). The results revealed (1) a large variation in transcription response to MCT and PUFA diets between UBO and LBO subjects, (2) higher sensitivity of UBO subjects to MCT/PUFA dietary intervention and (3) the upregulation of immune and apoptotic pathways and downregulation of metabolic pathways (oxidative, lipid, carbohydrate and amino acid metabolism) in UBO subjects when consuming MCT compared with PUFA diet. In conclusion, we report that despite the recommendation of MCT-based diet for improving obesity phenotype, this diet may have adverse effect on inflammatory and metabolic status of UBO subjects. The body fat distribution is, therefore, an important parameter to consider when providing personalized dietary recommendation. © 2009 The Author(s).
Subject
Biomedical Research
Dietary interventions
DNA microarrays
Long-chain fatty acids (PUFA)
Lower body obesity (LBO)
Medium-chain fatty acids (MCT)
Upper body obesity (UBO)
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http://resolver.tudelft.nl/uuid:45296274-fbb0-4034-a479-6073f9a74bda
DOI
https://doi.org/10.1007/s12263-009-0122-9
TNO identifier
241497
ISSN
1555-8932
Source
Genes and Nutrition, 4 (4), 143-149
Document type
article