Print Email Facebook Twitter The stokes number approach to support scale-up and technology transfer of a mixing process Title The stokes number approach to support scale-up and technology transfer of a mixing process Author Willemsz, T.A. Hooijmaijers, R. Rubingh, C.M. Frijlink, H.W. Vromans, H. van der Voort Maarschalk, K. Publication year 2012 Abstract Transferring processes between different scales and types of mixers is a common operation in industry. Challenges within this operation include the existence of considerable differences in blending conditions between mixer scales and types. Obtaining the correct blending conditions is crucial for the ability to break up agglomerates in order to achieve the desired blend uniformity. Agglomerate break up is often an abrasion process. In this study, the abrasion rate potential of agglomerates is described by the Stokes abrasion (Stokes number of the system. The Stokes number equals the ratio between the kinetic energy density of the moving powder bed and the work of fracture of the agglomerate. In this study, the Stokes approach demonstrates to be a useful tool to predict the abrasion of agglomerates during blending when technology is transferred between mixer scales/types. Applying the Stokes approach revealed a transition point between parameters that determined agglomerate abrasion. This study gave evidence that (1) below this transition point, agglomerate abrasion is determined by a combination of impeller effects and by the kinetic energy density of the powder blend, whereas (2) above this transition point, agglomerate abrasion is mainly determined by the kinetic energy density of the powder blend. © 2012 The Author(s). Subject LifeQS - Quality & SafetyEELS - Earth, Environmental and Life SciencesBiomedical InnovationBiologyHealthy Livingdry mixingscale-upstokes number To reference this document use: http://resolver.tudelft.nl/uuid:450d694e-4d90-464e-ac06-6998cd0df70c DOI https://doi.org/10.1208/s12249-012-9818-z TNO identifier 464280 ISSN 1530-9932 Source AAPS PharmSciTech, 13 (3), 928-933 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.