Title
Role of caveolin-1 in fibrotic diseases
Author
Gvaramia, D.
Blaauboer, M.E.
Hanemaaijer, R.
Everts, V.
Publication year
2013
Abstract
Fibrosis underlies the pathogenesis of numerous diseases and leads to severe damage of vital body organs and, frequently, to death. Better understanding of the mechanisms resulting in fibrosis is essential for developing appropriate treatment solutions and is therefore of upmost importance. Recent evidence suggests a significant antifibrotic potential of an integral membrane protein, caveolin-1. While caveolin-1 has been widely studied for its role in the regulation of cell signaling and endocytosis, its possible implication in fibrosis remains largely unclear. In this review we survey involvement of caveolin-1 in various cellular processes and highlight different aspects of its antifibrotic activity. We hypothesize that caveolin-1 conveys a homeostatic function in the process of fibrosis by (a) regulating TGF-β1 and its downstream signaling; (b) regulating critical cellular processes involved in tissue repair, such as migration, adhesion and cellular response to mechanical stress; and (c) antagonizing profibrotic processes, such as proliferation. Finally, we consider this homeostatic function of caveolin-1 as a possible novel approach in treatment of fibroproliferative diseases. © 2013 International Society of Matrix Biology.
Subject
Life
MHR - Metabolic Health Research
EELS - Earth, Environmental and Life Sciences
Biomedical Innovation
Biology
Healthy Living
Caveolin-1
CSD peptide
Fibrosis
Matrix remodeling
Mechanotransduction
TGF-β1
Antifibrotic agent
Recombinant caveolin 1
Transforming growth factor beta1
Unclassified drug
Animal experiment
Animal model
Animal tissue
Controlled study
Human
Mechanical stress
Mouse
Nonhuman
Protein function
Short survey
Tissue repair
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http://resolver.tudelft.nl/uuid:44ef87f1-1067-490a-be68-fd49acdc9aec
DOI
https://doi.org/10.1016/j.matbio.2013.03.005
TNO identifier
478804
ISSN
0945-053X
Source
Matrix Biology, 32 (6), 307-315
Document type
article