Title
A regulatory model for tissue differentiation using poroelastic theory
Author
van Driel, W.D.
Huiskes, R.
Prendergast, P.J.
TNO Bouw
Contributor
Thimus, J.F. (editor)
Abousleiman, Y. (editor)
Cheng, A.H.D. (editor)
Coussy, O. (editor)
Detournay, E. (editor)
Balkema, A.A. (editor)
Publication year
1998
Abstract
The introduction of poroelastic formulations into finite element analysis allowed a continuum approach to model soft hydrated tissues of the body, such as skin, cartilage, and fibrous connective tissue. The problem addressed in this study is the applicability of poroelasticity for the prediction of soft tissue differentiation processes found around prostheses. It has been postulated that these processes are modulated by mechanical stimuli. We developed a regulatory feedback model based on biophysical cellular stimuli of tissue strain and interstitial fluid flow. Poroelastic finite element analyses were used to calculate these stimuli. To assess its feasibility, the model was applied to a known implant-motion experimental model in dog bone, in which soft tissues were formed in the gap between implant and bone. Depending on the loading condition, the differentiation time-trajectory predicted from the regulatory model demonstrated the similarities between the model results and implant incorporation processes found in reality
Subject
Architecture and Building
To reference this document use:
http://resolver.tudelft.nl/uuid:438c8eae-6e37-44a0-bebd-880fd1ebe1dc
TNO identifier
329218
ISBN
9058090035
Source
Poromechanics. A Tribute to Maurice A. Biot. Proceedings of the BIOT Conference on Poromechanics, Louvain-La-Neuve, Belgium, 14-16 September 1998, 409-413
Document type
conference paper