Title
Pathways of Toxicity: T4 workshop
Author
Kleensang, A.
Maertens, A.
Rosenberg, M.
Fitzpatrick, S.
Lamb, J.
Auerbach, S.
Brennan, R.
Crofton, K.M.
Gordon, B.
Fornace Jr., A.J.
Gaido, K.
Gerhold, D.
Haw, R.
Henney, A.
Ma’ayan, A.
McBride, M.
Monti, S.
Ochs, M.F.
Pandey, A.
Sharan, R.
Stierum, R.
Tugendreich, Z.
Willett, C.
Wittwehr, C.
Xia, J.
Patton, G.W.
Arvidson, K.
Bouhifd, M.
Hogberg, H.T.
Luechtefeld, T.
Smirnova, L.
Zhao, L.
Adeleye, Y.
Kanehisa, M.
Carmichael, P.
Andersen, M.E.
Hartung, T.
Publication year
2014
Abstract
Despite wide-spread consensus on the need to transform toxicology and risk assessment in order to keep pace with technological and computational changes that have revolutionized the life sciences, there remains much work to be done to achieve the vision of toxicology based on a mechanistic foundation. A workshop was organized to explore one key aspect of this transformation – the development of Pathways of Toxicity (PoT) as a key tool for hazard identification based on systems biology. Several issues were discussed in depth in the workshop: The first was the challenge of formally defining the concept of a PoT as distinct from, but complementary to, other toxicological pathway concepts such as mode of action (MoA). The workshop came up with a preliminary definition of PoT as “A molecular definition of cellular processes shown to mediate adverse outcomes of toxicants”. It is further recognized that normal physiological pathways exist that maintain homeostasis and these, sufficiently perturbed, can become PoT. Second, the workshop sought to define the adequate public and commercial resources for PoT information, including data, visualization, analyses, tools, and use-cases, as well as the kinds of efforts that will be necessary to enable the creation of such a resource. Third, the workshop explored ways in which systems biology approaches could inform pathway annotation, and which resources are needed and available that can provide relevant PoT information to the diverse user communities.
Subject
Life
RAPID - Risk Assessment Products in Development
ELSS - Earth, Life and Social Sciences
Food and Nutrition
Toxicology
Healthy Living
Systems toxicology
Pathways of toxicity
Adverse outcome pathways
In vitro toxicology
Human toxome
To reference this document use:
http://resolver.tudelft.nl/uuid:42ec698f-4dc3-4675-a01e-48ff00fa3ccd
DOI
https://doi.org/10.14573/altex.1309261
TNO identifier
486889
Source
Altex, 31, 53-61
Document type
article