Title
Hypertension, antihypertensives and mutations in the Von Hippel-Lindau gene in renal cell carcinoma: Results from the Netherlands Cohort Study
Author
Schouten, L.J.
van Dijk, B.A.C.
Oosterwijk, E.
van de Hulsbergen-Kaa, C.A.
Kiemeney, L.A.L.M.
Goldbohm, R.A.
Schalken, J.A.
van den Brandt, P.A.
TNO Kwaliteit van Leven
Publication year
2005
Abstract
Objectives: Hypertension and/or antihypertensive medication are reported to be risk factors of renal cell carcinoma (RCC). We investigated whether these risk factors are associated with von Hippel-Lindau gene (VHL) mutations in RCC. Methods: The Netherlands Cohort Study on Diet and Cancer (NLCS) started in 1986 (n = 120 852 men and women) and uses the case-cohort methodology. After 11.3 years of follow-up, 337 RCC cases and 4774 subcohort members were available for analysis. DNA was isolated from paraffin-embedded tumour tissue for VHL analysis. Results: Cohort members who reported hypertension or use of antihypertensive medication had a slightly (non-significant) increased risk of RCC: rate ratios (RR) 1.22 [95% confidence interval (Cl), 0.94-1.58] and 1.14 (95% Cl, 0.85-1.52), respectively. RRs were adjusted for sex, age, body mass index (BMI) and cigarette smoking. Of the 235 patients for whom tumour tissue specimens were collected, 187 had a clear-cell RCC, of whom 114 had a VHL mutation. History of hypertension was associated with a non-significantly increased risk of clear-cell RCC with VHL mutations: RR = 1.34 (95% Cl, 0.87-2.07), and was not associated with the risk of clear-cell RCC without VHL mutations; RR = 0.88 (95% Cl, 0.51-1.53). Use of diuretics was associated with clear-cell RCC without VHL mutations; RR = 2.11 (95% Cl, 1.16-3.83). Conclusions: In this study non-significantly increased risks for history of hypertension and use of antihypertensive medication with RCC were observed. The association with hypertension was stronger in RCC patients with VHL mutations, while there was a positive association of diuretics use and risk of RCC without VHL mutations. © 2005 Lippincott Williams & Wilkins.
Subject
Biology
Food and Chemical Risk Analysis
Antihypertensive medication
Cohort study
Hypertension
Renal cell carcinoma
The Netherlands
VHL mutations
antihypertensive agent
diuretic agent
paraffin
von Hippel Lindau protein
adult
aged
article
body mass
cancer risk
cigarette smoking
cohort analysis
DNA isolation
female
gene mutation
genetic analysis
genetic risk
human
hypertension
kidney carcinoma
major clinical study
male
Netherlands
priority journal
Aged
Antihypertensive Agents
Carcinoma, Renal Cell
Case-Control Studies
Cohort Studies
Female
Follow-Up Studies
Humans
Hypertension
Kidney Neoplasms
Male
Middle Aged
Mutation
Netherlands
Risk Factors
Statistics
Treatment Outcome
Von Hippel-Lindau Tumor Suppressor Protein
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TNO identifier
238784
ISSN
0263-6352
Source
Journal of Hypertension, 23 (11), 1997-2004
Document type
article