Title
Volume overload cleanup: An approach for on-line SPE-GC, GPC-GC, and GPC-SPE-GC
Author
Kerkdijk, H.
Mol, H.G.J.
van der Nagel, B.
TNO Kwaliteit van Leven
Publication year
2007
Abstract
A new concept for cleanup, based on volume overloading of the cleanup column, has been developed for on-line coupling of gel permeation chromatography (GPC), solid-phase extraction (SPE), or both, to gas chromatography (GC). The principle is outlined and the applicability demonstrated by the determination of pesticide residues in food matrixes using integrated and automated cleanup-GC-MS. Compared to conventional approaches for on-line cleanup-GC, the new technique involves introduction of much smaller volumes (e.g., 2-20 μL) into the GC without sacrificing method LODs. The much smaller injection volumes involved greatly simplify on-line coupling, improve robustness, and increase attractiveness for implementation in routine laboratories. © 2007 American Chemical Society.
Subject
Biology
Analytical research
Gas chromatography
Gel permeation chromatography
Online systems
Pesticides
Cleanup column
Food matrixes
Solid phase extraction (SPE)
Volume overload cleanup
Extraction
article
chemical analysis
gas chromatography
gel permeation chromatography
laboratory test
mass spectrometry
online analysis
solid phase extraction
validation study
Chlorophyll
Chromatography, Gas
Chromatography, Gel
Fish Oils
Food Analysis
Pesticide Residues
Sensitivity and Specificity
Solid Phase Extraction
To reference this document use:
http://resolver.tudelft.nl/uuid:40abc93f-f434-4209-a631-f0bfb4b24b0e
DOI
https://doi.org/10.1021/ac0701536
TNO identifier
240278
ISSN
0003-2700
Source
Analytical Chemistry, 79 (21), 7975-7983
Document type
article