Title
Elevated osteopontin levels in active relapsing-remitting multiple sclerosis
Author
Vogt, M.H.J.
Lopatinskaya, L.
Smits, M.
Polman, C.H.
Nagelkerken, L.
TNO Preventie en Gezondheid
Publication year
2003
Abstract
In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within MS lesions. Here, we report significantly increased OPN protein levels in plasma of relapsing-remitting MS patients. In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels. Interestingly, active relapsing-remitting patients had higher OPN protein levels than patients without relapses. Chemicals/CAS: interferon beta serine, 90598-63-3; osteopontin, 106441-73-0; Osteopontin, 106441-73-0; Sialoglycoproteins; SPP1 protein, human
Subject
plasma protein
adult
clinical article
controlled study
disease activity
disease course
disease exacerbation
drug effect
follow up
gene expression
genetic code
pathogenesis
relapse
upregulation
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Multiple Sclerosis, Chronic Progressive
Multiple Sclerosis, Relapsing-Remitting
Osteopontin
Sialoglycoproteins
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DOI
https://doi.org/10.1002/ana.10606
TNO identifier
237110
ISSN
0364-5134
Source
Annals of Neurology, 53 (6), 819-822
Document type
article