Print Email Facebook Twitter Application of the Dutch, Finnish and British Screening Guidelines in a Cohort of Children with Growth Failure Title Application of the Dutch, Finnish and British Screening Guidelines in a Cohort of Children with Growth Failure Author Stalman, S.E. Hellinga, I. van Dommelen, P. Hennekam, R.C.M. Saari, A. Sankilampi, U. Dunkel, L. Wit, J.M. Kamp, G.A. Plötz, F.B. Publication year 2015 Abstract Aims: To evaluate three guidelines for selecting short children for diagnostic workup in a general pediatric clinic. Methods: All patients (n = 131) aged 3.00-9.99 years who were referred for growth failure to a general pediatric clinic were evaluated for their medical history and growth and examined. All of them underwent the same standardized diagnostic workup. Retrospectively, the criteria for the diagnostic workup from three guidelines (proposed in the Netherlands, Finland and the UK) were applied, and their sensitivity was assessed. A Dutch reference sample (n = 958) was used for calculating population specificity. Results: In 23 patients (17.6%), a pathological cause of their growth failure was found. The sensitivity of the original Dutch, Finnish and British guidelines was 73.9, 78.3 and 56.5% and their specificity 98.5, 83.7 and 95.8%, respectively. When adding recent growth deflection to the Dutch guideline, sensitivity increased to 87%, but specificity decreased markedly (to 87%). Conclusion: The proposed cutoff values for height standard deviation score and distance to target height/mid-parental height, as used in the Netherlands and Finland, are effective for population growth monitoring, and superior to the monitoring algorithm in the UK. Growth deflection irrespective of height is an important sign of acquired growth disorders, but its specificity is too low for population screening. Subject LifeCH - Child HealthELSS - Earth, Life and Social SciencesHealthy for LifeHealthHealthy LivingGrowth disordersGrowth monitoringHeight deflectionHeight standard deviation scoreTarget heightAlgorithmAssessment of humansBody heightChildChild growthClinical evaluationCohort analysisDiagnostic procedureFemaleFinlandMajor clinical studyMaleMedical historyNetherlandsParentPatient referralPediatric hospitalPractice guidelineScreening testSensitivity and specificityShort statureUnited Kingdom To reference this document use: http://resolver.tudelft.nl/uuid:3f191ea7-caf6-44a4-931b-c2c537a4f3d3 DOI https://doi.org/10.1159/000440652 TNO identifier 531051 Source Hormone Research in Pediatrics, 84 (6), 376-382 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.