Print Email Facebook Twitter Biological profiling of plasma neuropeptide Y in relation to posttraumatic stress symptoms in two combat cohorts Title Biological profiling of plasma neuropeptide Y in relation to posttraumatic stress symptoms in two combat cohorts Author Reijnen, A. Geuze, E. Eekhout, I. Maihofer, A.X. Nievergelt, C.M. Baker, D.G. Vermetten, E. Publication year 2018 Abstract In order to decrease the risk of developing stress-related disorders after military deployment, biological vulnerability factors should be identified. Neuropeptide Y (NPY) is a peptide neurotransmitter that is associated with modulation of the stress response. Using the data of two longitudinal prospective cohort studies (N = 892 and N = 2427), plasma NPY (pNPY) was assessed as a possible susceptibility biomarker for the development of PTSD symptoms over time. Data collection started prior to deployment and follow-up assessments were completed up to two years after deployment. In pNPY levels, measured before and shortly after deployment, three distinct trajectories were identified. In both cohorts, these trajectories were not related to the level of reported PTSD symptoms over time and neither were pre-deployment pNPY levels. Whereas previous research suggested that high NPY levels might be a marker for resilience, the current findings suggest limited usefulness of peripherally measured NPY in the development of PTSD. © 2018 Elsevier B.V. Chemicals/CAS: neuropeptide Y, 82785-45-3, 83589-17-7 Subject LifeCH - Child HealthELSS - Earth, Life and Social SciencesHealthy for LifeHealthHealthy LivingDeploymentMilitaryNeuropeptide YPosttraumatic stress disorderResilienceSusceptibility markerBiological markerNeuropeptide YAdultCohort analysisControlled studyDiagnostic valueFollow upHumanLongitudinal studyMajor clinical studyMaleMilitary deploymentposttraumatic stress disorderPriority journalProtein blood levelSensitivity and specificitySoldierWar To reference this document use: http://resolver.tudelft.nl/uuid:3efac881-f425-400d-9c07-889412c2ce71 DOI https://doi.org/10.1016/j.biopsycho.2018.02.008 TNO identifier 787785 ISSN 0301-0511 Source Biological Psychology, 134, 72-79 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.