Title
Biological profiling of plasma neuropeptide Y in relation to posttraumatic stress symptoms in two combat cohorts
Author
Reijnen, A.
Geuze, E.
Eekhout, I.
Maihofer, A.X.
Nievergelt, C.M.
Baker, D.G.
Vermetten, E.
Publication year
2018
Abstract
In order to decrease the risk of developing stress-related disorders after military deployment, biological vulnerability factors should be identified. Neuropeptide Y (NPY) is a peptide neurotransmitter that is associated with modulation of the stress response. Using the data of two longitudinal prospective cohort studies (N = 892 and N = 2427), plasma NPY (pNPY) was assessed as a possible susceptibility biomarker for the development of PTSD symptoms over time. Data collection started prior to deployment and follow-up assessments were completed up to two years after deployment. In pNPY levels, measured before and shortly after deployment, three distinct trajectories were identified. In both cohorts, these trajectories were not related to the level of reported PTSD symptoms over time and neither were pre-deployment pNPY levels. Whereas previous research suggested that high NPY levels might be a marker for resilience, the current findings suggest limited usefulness of peripherally measured NPY in the development of PTSD. © 2018 Elsevier B.V. Chemicals/CAS: neuropeptide Y, 82785-45-3, 83589-17-7
Subject
Life
CH - Child Health
ELSS - Earth, Life and Social Sciences
Healthy for Life
Health
Healthy Living
Deployment
Military
Neuropeptide Y
Posttraumatic stress disorder
Resilience
Susceptibility marker
Biological marker
Neuropeptide Y
Adult
Cohort analysis
Controlled study
Diagnostic value
Follow up
Human
Longitudinal study
Major clinical study
Male
Military deployment
posttraumatic stress disorder
Priority journal
Protein blood level
Sensitivity and specificity
Soldier
War
To reference this document use:
http://resolver.tudelft.nl/uuid:3efac881-f425-400d-9c07-889412c2ce71
DOI
https://doi.org/10.1016/j.biopsycho.2018.02.008
TNO identifier
787785
ISSN
0301-0511
Source
Biological Psychology, 134, 72-79
Document type
article