Title
Assessment of protein allergenicity on the basis of immune reactivity: Animal models
Author
Kimber, I.
Dearman, R.J.
Penninks, A.H.
Knipples, L.M.J.
Buchanan, R.B.
Hammerberg, B.
Jackson, H.A.
Helm, R.M.
Publication year
2003
Abstract
Because of the public concern surrounding the issue of the safety of genetically modified organisms, it is critical to have appropriate methodologies to aid investigators in identifying potential hazards associated with consumption of foods produced with these materials. A regent panel of experts convened by the Food and Agriculture Organization and World Health Organization suggested there is scientific evidence that using data from animal studies will contribute important information regarding the allergenicity of foods derived from biotechnology. This view has given further impetus to the development of suitable animal models for allergenicity assessment. This article is a review of what has been achieved and what still has to be accomplished regarding several different animal models. Progress made in the design and evaluation of models in the rat, the mouse, the dog and in swine is reviewed and discussed.
Subject
Toxicology
Toxicology and Applied Pharmacology
Allergy
Dog
Hazard identification
IgE
IgG
Immunogenicity
Mouse
Rat
Risk assessment
Swine
food allergen
protein
allergenicity
animal experiment
biotechnology
DNA modification
dog
food allergy
food intake
food safety
immunoreactivity
methodology
microorganism
nonhuman
priority journal
retrospective study
review
swine
world health organization
Administration, Oral
Animals
Dietary Proteins
Disease Models, Animal
Dogs
Food Hypersensitivity
Humans
Infusions, Parenteral
Mice
Mice, Inbred BALB C
Peanut Hypersensitivity
Rats
Risk Assessment
Swine
Animalia
Canis familiaris
Sus scrofa
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http://resolver.tudelft.nl/uuid:3b29679f-6702-4316-9a9d-b6a5705f25c8
TNO identifier
237204
ISSN
0091-6765
Source
Environmental Health Perspectives, 111 (8), 1125-1130
Document type
article