Print Email Facebook Twitter Stress proteins in CNS inflammation Title Stress proteins in CNS inflammation Author van Noort, J.M. TNO Kwaliteit van Leven Publication year 2008 Abstract Stress proteins or heat shock proteins (HSPs) are ubiquitous cellular components that have long been known to act as molecular chaperones. By assisting proper folding and transport of proteins, and by assisting in the degradation of aberrant proteins, they play key roles in cellular metabolism. The frequent accumulation of insoluble protein aggregates during chronic neurodegenerative disorders suggests failure of HSP functions to be a common denominator among such diseases. Recent developments have clarified that functions of HSPs extend well beyond their role in protein folding and degradation alone. Stress-inducible HSPs also regulate apoptosis, antigen presentation, inflammatory signalling pathways and, intriguingly, also serve as extracellular mediators of inflammation. Several receptors have been identified for extracellular HSPs, which control inflammatory pathways similar to those activated by cytokines and chemokines. In this review, both the traditional and the exciting novel functions of HSPs are discussed, with a focus on their relevance for neurodegeneration and neuroinflammation. Recent advances in this field suggest that HSPs represent attractive novel targets as well as therapeutic entities for CNS disorders. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Subject BiologyBiomedical ResearchBrainHeat shock proteinsInflammationNeurodegenerationcaspase 3chaperonecrystallinheat shock proteinheat shock protein 70heat shock protein 90I kappa Bimmunoglobulin enhancer binding proteinprotein bcl 2RANTEStau proteintoll like receptorAlexander diseaseAlzheimer diseaseantigen presentationantigen presenting cellapoptosiscentral nervous system diseasecytokine productioncytotoxic T lymphocytedegenerative diseasehumaninflammationnonhumanParkinson diseasepriority journalprotein aggregationprotein degradationprotein expressionprotein foldingprotein phosphorylationprotein structurereviewAntigen PresentationApoptosisEncephalomyelitisHeat-Shock ProteinsHumansInflammation MediatorsMolecular ChaperonesNeurodegenerative Diseases To reference this document use: http://resolver.tudelft.nl/uuid:38dd4067-f3b5-44de-9d0f-add7389e6dbf DOI https://doi.org/10.1002/path.2273 TNO identifier 240596 ISSN 0022-3417 Source Journal of Pathology, 214 (2), 267-275 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.