Print Email Facebook Twitter Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer Title Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer Author Ganesh, S. Sier, C.F.M. Griffioen, G. Vloedgraven, H.J.M. de Boer, A. Welvaart, K. van de Velde, C.J.H. van Krieken, J.H.J.M. Verheijen, J.H. Lamers, C.B.H.W. Verspaget, H.W. Instituut voor Verouderings- en Vaatziekten Onderzoek TNO Publication year 1994 Abstract Human colorectal carcinogenesis has been shown previously to be associated with impressive changes in the tissue levels of plasminogen activators and their inhibitors, exemplified by an increase in the urokinase-type plasminogen activator (u-PA) and the inhibitors PAI-1 and PAI-2, and a decrease in tissue-type plasminogen activator (t-PA). In the present study we evaluated the prognostic significance of these parameters to the overall survival of patients with colorectal cancer, in conjunction with several major clinicopathological parameters like age, gender, differentiation grade, and Dukes' stage. Univariate analyses revealed that a low t-PA antigen level, low t-PA activity, and high u-PA/t-PA antigen ratio in normal mucosa and a high u-PA and PAI-2 antigen level in carcinomas are prognostic for a poor overall survival of patients with colorectal cancer. The prognostic value of t-PA antigen and activity in normal mucosa, the antigen ratio of u-PA in carcinoma (C) and t-PA in corresponding normal (N) mucosa [u-PA(C)/t-PA(N) antigen ratio], and PAI-2 antigen in carcinomas was found to be independent from clinicopathological parameters by multivariate analyses. These observations illustrate the clinical importance of the plasminogen activation cascade at the tissue level in colorectal cancer invasion, metastasis, and survival. Subject AgedAged, 80 and overColorectal NeoplasmsFemaleFollow-Up StudiesHumanIntestinal MucosaMaleMiddle AgeMultivariate AnalysisNeoplasm StagingPrognosisTissue Plasminogen ActivatorUrinary Plasminogen Activator To reference this document use: http://resolver.tudelft.nl/uuid:361b2a82-197d-4812-8505-3a5f44f489a7 TNO identifier 280581 ISSN 0008-5472 Source Cancer Research, 54 (15), 4065-4071 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.