Title
Hemostasis and fibrinolysis in severe liver failure and their relation to hemorrhage
Author
Gaubius instituut TNO
Boks, A.L.
Brommer, E.J.P.
Schalm, S.W.
van Vliet, H.H.D.M.
Publication year
1986
Abstract
In a study of severe, decompensated liver failure, we tried to find a correlation between hemorrhage and parameters of hemostasis and fibrinolysis. Three groups of patients were studied: alcoholic cirrhosis; nonalcoholic cirrhosis, and acute liver failure without known prior liver disease. The two cirrhotic groups did not differ significantly from each other in coagulation or in fibrinolytic parameters, although liver function was more impaired in nonalcoholic cirrhosis. The levels of clotting factors, antithrombin III, prekallikrein, plasminogen and ??2-antiplasmin were significantly lower in the third group. Mean values of fibrinolytic activity (fibrin plate method) were slightly reduced as compared to normal in all three groups. Tissue plasminogen activator-related antigen tended to be elevated especially in alcoholic cirrhosis. The free fast-acting plasminogen activator inhibitor showed extremely high and extremely low levels in some patients among all three groups. Nonvariceal, capillary-type bleeding, including mucosal bleeding, hematomas and bleeding from puncture sites correlated with low thrombotest and normotest levels (p
Subject
alcohol liver cirrhosis
bleeding
blood and hemopoietic system
clinical article
digestive system
esophagus
esophagus varices
gastrointestinal hemorrhage
liver
liver failure
liver function
peripheral vascular system
portal hypertension
Acute Disease
Adult
Aged
Female
Fibrinolysis
Hemorrhage
Hemostasis
Hepatitis
Human
Liver Cirrhosis
Liver Cirrhosis, Alcoholic
Liver Diseases
Male
Middle Age
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TNO identifier
230061
ISSN
0270-9139
Source
Hepatology, 6 (6), 79-86
Document type
article