Print Email Facebook Twitter Raman Spectroscopy as a Promising Tool for Noninvasive Point-of-Care Glucose Monitoring Title Raman Spectroscopy as a Promising Tool for Noninvasive Point-of-Care Glucose Monitoring Author Scholtes-Timmerman, M.J. Bijlsma, S. Fokkert, M.J. Slingerland, R. van Veen, S.J.F. Publication year 2014 Abstract Self-monitoring of glucose is important for managing diabetes. Noninvasive glucose monitors are not yet available, but patients would benefit highly from such a device. We present results that may lead to a novel, point-of-care noninvasive system to measure blood glucose based on Raman spectroscopy. A hospitalized cohort of 111 subjects was measured using a custommade Raman spectrometer system. Blood glucose reference samples were used to correlate Raman data to glucose levels, using advanced preprocessing and analysis algorithms. A correlation coefficient (R2) of .83 was found correlating independent Raman-based predictions on reference blood glucose for the full cohort. Stratification of the cohort in gender-specific groups raised correlation levels to .88 (females) and .94 (males). Glucose could be measured noninvasively with average errors as low as 0.9 mM. We conclude that this novel system shows promising results for the advance of noninvasive, point-of-care glucose monitoring. Subject Life Earth / EnvironmentalRAPID - Risk Assessment Products in Development AEC - Applied Environmental ChemistryELSS - Earth, Life and Social SciencesFood and NutritionNutritionHealthy LivingBlood glucoseNoninvasivePoint of careRaman spectroscopySelf-monitoring of blood glucoseAnalysisBlood glucose monitoringDevicesGlucose blood levelHospital information systemProceduresVery elderlyAdultAgedAged, 80 and overBlood Glucose Self-MonitoringFemaleHumansMaleMiddle AgedMonitoring, PhysiologicPoint-of-Care SystemsSpectrum Analysis, Raman To reference this document use: http://resolver.tudelft.nl/uuid:34a42ca9-67f2-46b2-afeb-86f5e1cdcc1e DOI https://doi.org/10.1177/1932296814543104 TNO identifier 507738 Source Journal of Diabetes Science and Technology, 8 (5), 1354-1361 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.