Title
Plasma annexin A5 level relates inversely to the severity of coronary stenosis
Author
van Tits, L.J.H.
van Heerde, W.L.
van der Vleuten, G.M.
de Graaf, J.
Grobbee, D.E.
van de Vijver, L.P.L.
Stalenhoef, A.F.
Princen, H.M.
TNO Kwaliteit van Leven
Publication year
2007
Abstract
Exogenous radiolabeled annexin A5 is taken up by atherosclerotic tissue. We measured endogenous plasma annexin A5 and circulating oxidized low-density lipoprotein (oxLDL), a biochemical marker of atherosclerosis, in men with either severe angiographically determined coronary stenosis (n = 90) or no or only minor stenosis (n = 96). Men without history of cardiac disease or treatment and free of plaques in the carotid artery (by ultrasonography) were taken as controls (n = 87). Opposite to oxLDL, annexin A5 decreased at increasing severity of stenosis. OxLDL was lowest and annexin A5 was highest in controls. Percentage differences between groups were higher for annexin A5 than for oxLDL, and highest for oxLDL/annexin A5 ratio. The oxLDL/annexin A5 ratio is a better marker of the severity of coronary stenosis than oxLDL alone, may reflect the presence and extent of the atherosclerotic cardiovascular disease, and might prove useful for preclinical screening purposes. © 2007 Elsevier Inc. All rights reserved.
Subject
Biology
Biomedical Research
Angiography
Annexin A5
Atherosclerosis
Cardiovascular diseases
Coronary disease
Coronary stenosis
Oxidized low-density lipoprotein
Oxidized phospholipids
biological marker
lipocortin 5
oxidized low density lipoprotein
adult
aged
article
atherosclerosis
cardiovascular risk
controlled study
coronary artery obstruction
disease severity
female
human
lipid peroxidation
major clinical study
male
priority journal
protein blood level
risk assessment
risk factor
Aged
Aged, 80 and over
Annexin A5
C-Reactive Protein
Carotid Arteries
Cohort Studies
Coronary Angiography
Coronary Stenosis
Humans
Lipoprotein(a)
Lipoproteins, LDL
Male
Middle Aged
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http://resolver.tudelft.nl/uuid:32da58fe-a8c1-4272-a2be-9ed70841f4ba
DOI
https://doi.org/10.1016/j.bbrc.2007.03.020
TNO identifier
239978
ISSN
0006-291X
Source
Biochemical and Biophysical Research Communications, 356 (3), 674-680
Document type
article