Print Email Facebook Twitter Plasma annexin A5 level relates inversely to the severity of coronary stenosis Title Plasma annexin A5 level relates inversely to the severity of coronary stenosis Author van Tits, L.J.H. van Heerde, W.L. van der Vleuten, G.M. de Graaf, J. Grobbee, D.E. van de Vijver, L.P.L. Stalenhoef, A.F. Princen, H.M. TNO Kwaliteit van Leven Publication year 2007 Abstract Exogenous radiolabeled annexin A5 is taken up by atherosclerotic tissue. We measured endogenous plasma annexin A5 and circulating oxidized low-density lipoprotein (oxLDL), a biochemical marker of atherosclerosis, in men with either severe angiographically determined coronary stenosis (n = 90) or no or only minor stenosis (n = 96). Men without history of cardiac disease or treatment and free of plaques in the carotid artery (by ultrasonography) were taken as controls (n = 87). Opposite to oxLDL, annexin A5 decreased at increasing severity of stenosis. OxLDL was lowest and annexin A5 was highest in controls. Percentage differences between groups were higher for annexin A5 than for oxLDL, and highest for oxLDL/annexin A5 ratio. The oxLDL/annexin A5 ratio is a better marker of the severity of coronary stenosis than oxLDL alone, may reflect the presence and extent of the atherosclerotic cardiovascular disease, and might prove useful for preclinical screening purposes. © 2007 Elsevier Inc. All rights reserved. Subject BiologyBiomedical ResearchAngiographyAnnexin A5AtherosclerosisCardiovascular diseasesCoronary diseaseCoronary stenosisOxidized low-density lipoproteinOxidized phospholipidsbiological markerlipocortin 5oxidized low density lipoproteinadultagedarticleatherosclerosiscardiovascular riskcontrolled studycoronary artery obstructiondisease severityfemalehumanlipid peroxidationmajor clinical studymalepriority journalprotein blood levelrisk assessmentrisk factorAgedAged, 80 and overAnnexin A5C-Reactive ProteinCarotid ArteriesCohort StudiesCoronary AngiographyCoronary StenosisHumansLipoprotein(a)Lipoproteins, LDLMaleMiddle Aged To reference this document use: http://resolver.tudelft.nl/uuid:32da58fe-a8c1-4272-a2be-9ed70841f4ba DOI https://doi.org/10.1016/j.bbrc.2007.03.020 TNO identifier 239978 ISSN 0006-291X Source Biochemical and Biophysical Research Communications, 356 (3), 674-680 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.