Print Email Facebook Twitter The production of "bacteria-free" mice. Relationship between fecal flora and bacterial population of the skin Title The production of "bacteria-free" mice. Relationship between fecal flora and bacterial population of the skin Author Radiobiological Institute TNO van der Waaij, D. Sturm, C.A. Publication year 1971 Abstract In mice, after a few days of oral treatment with antibiotics which are minimally absorbed, the bacterial fecal flora is eliminated. In the course of such treatment, the bacterial population of the skin becomes drastically reduced. After 9 weeks, cultures from the skin of the back are negative. Following 12 weeks of treatment, about 50% of the mice are shown to be persistently free of microbes that are detectable by conventional methods of culturing. Disinfection of the skin (chlorhexidine) on the fourth day of treatment had no effect on the time required to obtain negative "whole-body cultures" in these animals. © 1971 Swets & Zeitlinger. Chemicals/CAS: bacitracin, 1405-87-4; neomycin, 11004-65-2, 1404-04-2, 1405-10-3, 8026-22-0; streptomycin, 57-92-1; Antibiotics; Bacitracin, 1405-87-4; Biguanides; Neomycin, 1404-04-2; Streptomycin, 57-92-1 Subject Antibiotic agentMicrobiologytimeAnimalAntibioticsBacillusBacitracinBiguanidesEnterobacteriaceaeFecesFemaleGerm-Free LifeMaleMiceMicrobial Sensitivity TestsNeomycinSkinStaphylococcusStreptomycinTime Factors To reference this document use: http://resolver.tudelft.nl/uuid:32c556d7-8dc2-4d97-93de-520e90d6991f DOI https://doi.org/10.1007/bf02218475 TNO identifier 227291 Publisher Kluwer Academic Publishers ISSN 0003-6072 Source Antonie van Leeuwenhoek, 37 (37), 139-151 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.