Title
The production of "bacteria-free" mice. Relationship between fecal flora and bacterial population of the skin
Author
Radiobiological Institute TNO
van der Waaij, D.
Sturm, C.A.
Publication year
1971
Abstract
In mice, after a few days of oral treatment with antibiotics which are minimally absorbed, the bacterial fecal flora is eliminated. In the course of such treatment, the bacterial population of the skin becomes drastically reduced. After 9 weeks, cultures from the skin of the back are negative. Following 12 weeks of treatment, about 50% of the mice are shown to be persistently free of microbes that are detectable by conventional methods of culturing. Disinfection of the skin (chlorhexidine) on the fourth day of treatment had no effect on the time required to obtain negative "whole-body cultures" in these animals. © 1971 Swets & Zeitlinger. Chemicals/CAS: bacitracin, 1405-87-4; neomycin, 11004-65-2, 1404-04-2, 1405-10-3, 8026-22-0; streptomycin, 57-92-1; Antibiotics; Bacitracin, 1405-87-4; Biguanides; Neomycin, 1404-04-2; Streptomycin, 57-92-1
Subject
Antibiotic agent
Microbiology
time
Animal
Antibiotics
Bacillus
Bacitracin
Biguanides
Enterobacteriaceae
Feces
Female
Germ-Free Life
Male
Mice
Microbial Sensitivity Tests
Neomycin
Skin
Staphylococcus
Streptomycin
Time Factors
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DOI
https://doi.org/10.1007/bf02218475
TNO identifier
227291
Publisher
Kluwer Academic Publishers
ISSN
0003-6072
Source
Antonie van Leeuwenhoek, 37 (37), 139-151
Document type
article