Print Email Facebook Twitter Nationwide age references for sitting height, leg length, and sitting height/height ratio, and their diagnostic value for disproportionate growth disorders Title Nationwide age references for sitting height, leg length, and sitting height/height ratio, and their diagnostic value for disproportionate growth disorders Author Fredriks, A.M. van Buuren, S. van Heel, W.J.M. Dijkman-Neerincx, R.H.M. Verloove-Vanhorick, S.P. Wit, J.M. TNO Kwaliteit van Leven Publication year 2005 Abstract Aims: To obtain age references for sitting height (SH), leg length (LL), and SH/H ratio in the Netherlands; to evaluate how SH standard deviation score (SDS), LL SDS, SH/H SDS, and SH/LL SDS are related to height SDS; and to study the usefulness of height corrected SH/H cut-off lines to detect Marfan syndrome and hypochondroplasia. Methods: Cross-sectional data on height and sitting height were collected from 14 500 children of Dutch origin in the age range 0-21 years. Reference SD charts were constructed by the LMS method. Correlations were analysed in three age groups. SH/H data from patients with Marfan syndrome and genetically confirmed hypochondroplasia were compared with height corrected SH/H references. Results: A positive association was observed between H SDS, SH SDS, and LL SDS in all age groups. There was a negative correlation between SH/H SDS and height SDS. In short children with a height SDS <-2 SDS, a cut-off limit of +2.5 SD leads to a more acceptable percentage of false positive results. In exceptionally tall children, a cut-off limit of -2.2 SDS can be used. Alternatively, a nomogram of SH/H SDS versus H SDS can be helpful. The sensitivity of the height corrected cut-off lines for hypochondroplasia was 80% and for Marfan syndrome only 30%. Conclusions: In exceptionally short or tall children, the dependency of the SH/H ratio (SDS) on height SDS has to be taken into consideration in the evaluation of body proportions. The sensitivity of the cut-off lines for hypochondroplasia is fair. Subject HealthJeugd en GezondheidDiagnostic procedureGrowth disorderHypochondroplasiaLeg lengthMajor clinical studyMarfan syndromeNewbornNomogramReference valueSittingAdolescentAdultAge FactorsAnthropometryBody HeightBone DiseasesChildChild, PreschoolCross-Sectional StudiesCrown-Rump LengthFemaleHumansInfantInfant, NewbornLegMaleMarfan SyndromeNetherlandsPostureReference ValuesRegression Analysis To reference this document use: http://resolver.tudelft.nl/uuid:31dc9255-f944-42f5-aceb-24125c19cee4 DOI https://doi.org/10.1136/adc.2004.050799 TNO identifier 238630 ISSN 0003-9888 Source Archives of Disease in Childhood, 90 (8), 807-812 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.