Print Email Facebook Twitter Food allergy: What do we learn from animal models? Title Food allergy: What do we learn from animal models? Author Knippels, L.M.J. van Wijk, F. Penninks, A.H. TNO Voeding Publication year 2004 Abstract Purpose of review This review summarizes selected articles on animal models of food allergy published in 2003. The research areas that are covered include mechanistic studies, the search for new therapies, as well as screening models for hazard identification of potential allergens. Recent findings Novel treatment options of both prevention and therapeutic strategies have been reported with promising results. The induction of de-sensitization to food proteins was achieved by exposure to a mixture of recombinant food allergens and T helper 1 (Th1)-skewing bacterial components. Furthermore, research in animal models has provided new insights into the role of protein structure, digestion, and gut permeability in sensitization and tolerance induction to food proteins. The Th2 hypothesis of food allergy was tested in mouse strains, linking genetic susceptibility to sensitization with differential Th1-Th2 responses. In this context, the role of the liver in development of food antigen-specific Th2 cells, and the importance of costimulatory molecules in Th2 skewing were demonstrated. Finally, rodent models to predict potential allergenicity of novel foods have been further developed using different routes of sensitization. Summary Currently, several animal models of food allergy are used, including mouse, rat, swine, and dog. Continuing research in these models may elucidate the immunological mechanisms that underlie the sensitization and challenge phase of food allergy and may result in improved therapeutic options. Furthermore, the development of animal models to predict relative allergenicity of novel foods remains an important topic. Subject HealthToxicology and Applied PharmacologyAllergenicityAnimal modelsFood allergyTherapyAra h 1 allergenAra h 2 allergenAra h 3 allergenDNA vaccinefood allergenfungal immunomodulatory proteinfungal proteinimmunoglobulin E antibodyprotein fip fverecombinant antigenrecombinant cytokinerecombinant peanut allergenunclassified drugallergenicityantigen specificityarticlebacteriumclinical researchdesensitizationdogdose responsedrug activitydrug mechanismdrug researchdrug screeningfood allergygenetic susceptibilityhealth hazardhypothesisimmunological toleranceimmunopathogenesisimmunoprophylaxismouse strainnonhumanpathophysiologypredictionpriority journalprotein degradationprotein dietprotein intakeprotein structurepublicationrat strainreviewscreening testsensitizationswineTh1 cellTh2 cellAnimalsFood HypersensitivityHumansImmunotherapyInterleukin-10Interleukin-4Models, AnimalT-Lymphocytes To reference this document use: http://resolver.tudelft.nl/uuid:2df166b5-925d-4923-8284-5eb4e4923805 DOI https://doi.org/10.1097/00130832-200406000-00012 TNO identifier 237776 ISSN 1528-4050 Source Current Opinion in Allergy and Clinical Immunology, 4 (3), 205-209 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.