Print Email Facebook Twitter Differential susceptibility of rats and guinea pigs to the ototoxic effects of ethyl benzene Title Differential susceptibility of rats and guinea pigs to the ototoxic effects of ethyl benzene Author Cappaert, N.L.M. Klis, S.F.L. Muijser, H. Kulig, B.M. Ravensberg, L.C. Smoorenburg, G.F. Centraal Instituut voor Voedingsonderzoek TNO Publication year 2002 Abstract The present study was designed to compare the ototoxic effects of volatile ethyl benzene in guinea pigs and rats. Rats showed deteriorated auditory thresholds in the mid-frequency range, based on electrocochleography, after 550-ppm ethyl benzene (8 h/day, 5 days). Outer hair cell (OHC) loss was found in the corresponding cochlear regions. In contrast, guinea pigs showed no threshold shifts and no OHC loss after exposure to much higher ethyl benzene levels (2500 ppm, 6 h/day, 5 days). Subsequently, a limited study (four rats and four guinea pigs) was performed in an attempt to understand these differences in susceptibility. Ethyl benzene concentration in blood was determined in both species after exposure to 500-ppm ethyl benzene (8 h/day, 3 days). At the end of the first day, blood of the rats contained 23.2±0.8-μg/ml ethyl benzene, whereas the concentration in guinea pig blood was 2.8±0.1 μg/ml. After 3 days, the concentration in both species decreased with respect to the first day, but the ethyl benzene concentration in rat blood was still 4.3 times higher than that in guinea pig blood. Thus, the difference in susceptibility between the species may be related to the ethyl benzene concentration in blood. © 2002 Elsevier Science Inc. All rights reserved. Chemicals/CAS: Benzene Derivatives; ethylbenzene, 100-41-4 Subject NutritionAcoustic StimulationAnimalAudiometry, Evoked ResponseBenzene DerivativesChromatography, GasCochleaComparative StudyEvoked Potentials, AuditoryFemaleGenetic Predisposition to DiseaseGuinea PigsRatsRats, Inbred StrainsSpecies SpecificityAnimalsCaviaCavia porcellusSus scrofa To reference this document use: http://resolver.tudelft.nl/uuid:2be78894-8d62-41e6-8122-5b6630757e8f DOI https://doi.org/10.1016/s0892-0362(02)00208-8 TNO identifier 42378 ISSN 0892-0362 Source Neurotoxicology and Teratology, 24 (4), 503-510 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.