Title
The development of a specific detector for biological warfare agent particles
Author
Kievit, O.
Busker, R.W.
Kientz, C.E.
Marijnissen, J.C.M.
Publication year
2003
Abstract
This paper describes the latest achievements in the development of a new rapid detector for biological warfare agents (BWA). The system uses aerodynamic particle sizing and matrix-assisted laser desorption/ionisation aerosol time-of-flight mass spectrometry (MALDI ATOFMS) to analyse individual aerosol particles sampled directly from the atmosphere. The capabilities of the system were significantly improved with regard to the mass range, sensitivity and specificity for biological particles. The analysis of single aerosol particles of large biomolecules (peptides and proteins), as well as bacteria (E. coli) and spores (Bacillus subtilis), has been demonstrated.
Subject
Biodetectors
Biological warfare agents (BWA)
Polymerase chain reaction (PCR)
Ultraviolet absorption
Aerodynamics
Aerosols
Biological materials
Biomarkers
Biotechnology
Charge coupled devices
Escherichia coli
Fluorescence
Ionization
Mass spectrometers
Photomultipliers
Ultraviolet devices
Chemical warfare
Observation, Weapon & Protection Systems
CBRN - CBRN Protection
ELSS - Earth, Life and Social Sciences
To reference this document use:
http://resolver.tudelft.nl/uuid:28de8249-96d5-42a0-84ad-009ba32987a9
TNO identifier
237447
ISSN
0083-5560
Source
VDI Berichte, 111-116
Document type
article