DNA damage, repair and tanning acceleration
van den Berg, P.T.M.
Centraal Instituut voor Voedingsonderzoek TNO
Exposure of the skin to solar ultraviolet radiation (UV) leads to various adverse effects, such as the induction of cellular damage and mutations, suppression of the skin's immune system, and the induction of skin cancer. These effects are the consequence of various molecular alterations in the skin resulting from absorption of photons. Formation of DNA damage is one of these. In the present study the effect of tanning accelerators was investigated on the level of DNA damage after exposure to UV. With the use of a specific monoclonal antibody, DNA damage was quantified in human skin. Epicutaneous application of a complex of tanning enhancers (Unipertan® VEG-2002) before exposure to UV was found to reduce the level of DNA damage at 6 and/or 24 h thereafter. The results of in vitro studies (human skin organ cultures) as well as of a preliminary clinical trial are presented. The tanning enhancer was shown to increase removal of UV-DNA damage over normal repair measured at 6 and 24 h after UV exposure.
To reference this document use:
Journal of Cosmetic Science, 50 (6), 341-349