Title
Inhibition of MLC responder and stimulator function with allo-antisera in rhesus monkeys
Author
Widmer, M.B.
Balner, H.
Primatencentrum TNO
Publication year
1978
Abstract
Ten antisera containing antibodies directed against specificities controlled by the Ia1 locus of rhesus monkeys were tested for their ability to inhibit the MLC reaction. In cultures with responding cells from the serum producer, all sera with anti-Ia1, activity depressed the stimulatory capacity of cells carrying the Ia1 antigen in question. In other responder/stimulator combinations, the stimulation-inhibition was Ia1 -related for the majority of the antisera. These data provide further evidence for a possible identity (or close association on the cell membrane) between Ia1 and D locus determinants of rhesus monkeys. In addition, some sera showed an inhibitory effect also on responder cells (with cells from the serum producer as stimulators). There was no apparent relation of response inhibition to the Ia1 specificities detected by the antisera. Chemicals/CAS: Epitopes; Histocompatibility Antigens; Immune Sera; Isoantibodies
Subject
Animal
Antibody Specificity
Binding, Competitive
Cytotoxicity Tests, Immunologic
Epitopes
Haplorhini
Histocompatibility Antigens
Immune Sera
Isoantibodies
Lymphocyte Culture Test, Mixed
Macaca mulatta
Male
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TNO identifier
228461
ISSN
0001-2815
Source
Tissue Antigens, 12 (2), 115-131
Document type
article