Print Email Facebook Twitter Nutrition in the prevention of gastrointestinal cancer Title Nutrition in the prevention of gastrointestinal cancer Author van den Brandt, P.A. Goldbohm, R.A. TNO Kwaliteit van Leven Publication year 2006 Abstract Diet has been hypothesized to play a role in the etiology of gastrointestinal cancer for a long time. Initially, strong evidence of such effects was found in retrospective epidemiological studies. Dietary habits, in particular those from the distant past, are difficult to measure, however. Results from recent, prospective and larger studies of better quality did not always confirm these associations. Consumption of fruits and vegetables appear to have a modest role in the prevention of gastrointestinal cancers. In contrast, the roles of alcohol consumption and overweight on risk of gastrointestinal cancer have become much clearer. Overweight and obesity are important risk factors for adenocarcinoma (but not squamous carcinoma) of the esophagus, gastric cardia carcinoma (but not noncardia carcinoma), and colorectal cancer, the latter in particular among men. Alcohol consumption is a risk factor for squamous carcinoma (but not adenocarcinoma) of the esophagus, gastric cancer and colorectal cancer. Selenium may be inversely related to esophageal and gastric cancer. © 2006 Elsevier Ltd. All rights reserved. Subject HealthFood and Chemical Risk Analysisalcohol consumptionbody weightcolorectal neoplasmsepidemiologyesophageal neoplasmsfruitpancreatic neoplasmsstomach neoplasmsvegetablesalcoholalpha tocopherolantioxidantascorbic acidbeta carotenecarotenoidheterocyclic aminenitratenitritenitrosamineplacebopolycyclic aromatic hydrocarbonriboflavinseleniumvitamin Dalcohol consumptionarticlecancer riskcancer susceptibilitycarcinogenesiscardia carcinomacigarette smokingcolorectal cancerdairy productdiet therapydietary fiberdietary intakedigestive system cancerdisease associationeating habitepidemiological dataesophageal adenocarcinomafood intakefood processingfruithumanhypothesismeatnon insulin dependent diabetes mellitusobesitypancreas cancerphysical activityrisk factorsquamous cell carcinomastomach cancervegetableAlcohol DrinkingBody Mass IndexDietGastrointestinal NeoplasmsHumansPancreatic Neoplasms To reference this document use: http://resolver.tudelft.nl/uuid:27b80c81-4834-4ca8-a081-ef1474e3d500 DOI https://doi.org/10.1016/j.bpg.2006.04.001 TNO identifier 239325 ISSN 1521-6918 Source Best Practice and Research: Clinical Gastroenterology, 20 (3), 589-603 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.