Print Email Facebook Twitter Skin deep: Enhanced sleep depth by cutaneous temperature manipulation Title Skin deep: Enhanced sleep depth by cutaneous temperature manipulation Author Raymann, R.J.E.M. Swaab, D.F. Van Someren, E.J.W. TNO Defensie en Veiligheid Publication year 2008 Abstract With ageing, an increasingly disturbed sleep is reported as a significant complaint affecting the health and well-being of many people. The available treatments for sleep disturbance have their limitations, so we have adopted a different approach to the improvement of sleep. Since in animal and human studies skin warming has been found to increase neuronal activity in brain areas that are critically involved in sleep regulation, we investigated whether subtle skin temperature manipulations could improve human sleep. By employing a thermosuit to control skin temperature during nocturnal sleep, we demonstrate that induction of a mere 0.4uC increase in skin temperature, whilst not altering core temperature, suppresses nocturnal wakefulness (P_0.001) and shifts sleep to deeper stages (P_0.001) in young and, especially, in elderly healthy and insomniac participants. Elderly subjects showed such a pronounced sensitivity, that the induced 0.4uC increase in skin temperature was sufficient to almost double the proportion of nocturnal slow wave sleep and to decrease the probability of early morning awakening from 0.58 to 0.04.Therefore, skin warming strongly improved the two most typical age-related sleep problems; a decreased slow wave sleep and an increased risk of early morning awakening. EEG frequency spectra showed enhancement of low-frequency cortical oscillations.The results indicate that subtle feedback control of in-bed temperature through very mild manipulations could have strong clinical relevance in the management of disturbed sleep especially in the elderly, who have an attenuated behavioural response to suboptimal environmental temperature, which may hamper them fromtaking appropriate action to optimize their bed temperature. Keywords: insomnia; sleep; ageing; temperature manipulation; thermoregulation; electroencephalographySubtiele manipulatie van de huidtemperatuur heeft een groot effect op slaap van ouderen; met milde huidverwarming neemt de kans dat een oudere om 6.00 uur 's ochtends wakker neemt af van 58 procent tot 4 procent en verdubbelt de hoeveelheid diepe slaap gedurende de nacht. Subject AgeingElectroencephalographyInsomniaSleepTemperature manipulationThermoregulationAgedAgingElectroencephalogramSkin temperatureSlow wave sleepWakefulnessAdultBody Temperature RegulationBrainHeatingHumansMiddle AgedPolysomnographySkin TemperatureSleep Stages To reference this document use: http://resolver.tudelft.nl/uuid:27402eea-840d-4f31-bef6-e4354548486b DOI https://doi.org/10.1093/brain/awm315 TNO identifier 19418 Source Brain, 500-513 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.