Print Email Facebook Twitter Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps Title Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps Author Loizou, G. Spendiff, M. Barton, H.A. Bessems, J. Bois, F.Y. d'Yvoire, M.B. Buist, H. Clewell III, H.J. Meek, B. Gundert-Remy, U. Goerlitz, G. Schmitt, W. TNO Kwaliteit van Leven KvL Publication year 2008 Abstract The increasing use of tissue dosimetry estimated using pharmacokinetic models in chemical risk assessments in various jurisdictions necessitates the development of internationally recognized good modelling practice (GMP). These practices would facilitate sharing of models and model evaluations and consistent applications in risk assessments. Clear descriptions of good practices for (1) model development i.e., research and analysis activities, (2) model characterization i.e., methods to describe how consistent the model is with biology and the strengths and limitations of available models and data, such as sensitivity analyses, (3) model documentation, and (4) model evaluation i.e., independent review that will assist risk assessors in their decisions of whether and how to use the models, and also model developers to understand expectations for various purposes e.g., research versus application in risk assessment. Next steps in the development of guidance for GMP and research to improve the scientific basis of the models are described based on a review of the current status of the application of physiologically based pharmacokinetic (PBPK) models in risk assessments in Europe, Canada, and the United States at the International Workshop on the Development of GMP for PBPK Models in Greece on April 27-29, 2007. Crown Copyright © 2008. Subject HealthGood modelling practicePBPKRisk assessmentarticleCanadadocumentationdosimetryEuropeGreecepriority journalrisk assessmentscientific literatureUnited StatesAnimalsHumansLegislation, DrugModels, StatisticalPharmacokineticsQuantitative Structure-Activity RelationshipRisk Assessment To reference this document use: http://resolver.tudelft.nl/uuid:23b11ef3-6363-46d6-8156-7a3e8dbc5767 DOI https://doi.org/10.1016/j.yrtph.2008.01.011 TNO identifier 240748 ISSN 0273-2300 Source Regulatory Toxicology and Pharmacology, 50 (3), 400-411 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.