Print Email Facebook Twitter Cardiovascular instability and baroreflex activity in a patient with tetanus Title Cardiovascular instability and baroreflex activity in a patient with tetanus Author van Lieshout, J.J. Wieling, W. Settels, J.J. Karemaker, J.M. TNO Biomedical Instrumentation Publication year 1991 Abstract In a patient with tetanus we tested the hypothesis that the hyperadrenergic cardiovascular instability might be due to impairment of the baroreceptor reflex by the tetanus toxin. Baroreflex sensitivity assessed with the phenylephrine method was found to be normal. Changes in arterial pressure correlated inversely with relative changes in plasma volume but not with plasma catecholamine levels. There were both extreme hypo- and hyperadrenergic episodes. We conclude that sympathetic overactivity in tetauns temporarily overrules a functionally intact baroreflex leading to severe blood pressure instability with episodes of hypertension. Subject Blood pressureCatecholaminesHeart rateAbscessCardiovascular systemHeart stroke volumeHemodynamicsPathophysiologyPhysiologyPressoreceptorTetanusVascular resistanceCardiac Output To reference this document use: http://resolver.tudelft.nl/uuid:23a2bcd6-8c82-4390-855f-535cacde0eec TNO identifier 280659 Publisher Springer ISSN 0959-9851 Source Clinical Autonomic Research, 1 (1), 5-8 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.