Title
Matrix metalloproteinase activity in equine synovial fluid: Influence of age, osteoarthritis, and osteochondrosis
Author
Gaubius Instituut TNO
Brama, P.A.J.
TeKoppele, J.M.
Beekman, B.
van Weeren, P.R.
Barneveld, A.
Publication year
1998
Abstract
Objective - To investigate the influence of age, osteoarthritis (OA), and osteochondrosis (OC) on the matrix metalloproteinase (MMP) activity in the synovial fluid (SF) of equine joints. Methods - SF was collected from normal and osteoarthritic metacarpophalangeal joints (normal: 14 adult, 28 juvenile; OA: 22 adult). And from normal and osteochondrotic tarsocrural joints (5 months: 11 normal, 8 OC; 11 months: 7 normal, 6 OC). Subsequently, overall MMP activity was measured. Results - The level of active MMPs was almost twofold higher in SF from juvenile horses (age up to 11 months) than in SF from mature animals (4-30 years; p
Subject
Biomedical Research
Matrix metalloproteinase
Age
Animal tissue
Cartilage degeneration
Cartilage matrix
Controlled study
Enzyme activity
Horse
Metacarpophalangeal joint
Nonhuman
Osteoarthritis
Osteochondrosis
Priority journal
Synovial fluid
Tarsal joint
Age Factors
Animals
Biological Markers
Fluorometry
Horse Diseases
Horses
Metalloendopeptidases
Osteoarthritis
Osteochondritis
Synovial Fluid
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DOI
https://doi.org/10.1136/ard.57.11.697
TNO identifier
234858
ISSN
0003-4967
Source
Annals of the Rheumatic Diseases, 57 (57), 697-699
Document type
article