Title
The Impact of COVID-19 Regulations on Adherence to Recombinant Human Growth Hormone Therapy: Evidence from Real-World Data
Author
van Dommelen, P.
Barios, R.M.
Arnaud, L.
le Masne, Q.
Koledova, E.
Publication year
2023
Abstract
Worldwide regulations during COVID-19 positively and negatively impacted self-management in paediatric patients with chronic medical conditions. We investigated the impact of regulations on adherence to recombinant human growth hormone (r-hGH) therapy in paediatric patients with growth disorders, using real-world adherence data extracted March 2019–February 2020 (before COVID-19) and March 2020–February 2021 (during COVID-19) from the easypod™ connect ecosystem. Data from three measures of regulations were analysed: stringency index (SI), school closure and stay-at-home. The mean SI, and the proportion of days with required school closure or stay-at-home during COVID-19 were categorised as high versus medium/low based on the 75th percentile. Adherence was categorised as optimal (≥85%) versus suboptimal (
Subject
Adherence
COVID-19
Growth disorders
Injection device
Lockdown
Recombinant human growth hormone (r-hGH)
Paediatric
Patients
Hormone
Therapy
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http://resolver.tudelft.nl/uuid:2311e7e5-b260-4a7b-a9fd-7888c809396b
DOI
https://doi.org/10.3390/endocrines4010017
TNO identifier
982927
Source
Endocrines, 4 (4), 194-204
Document type
article