Title
Updated population minimal eliciting dose distributions for use in risk assessment of 14 priority food allergens
Author
Remington, B.C.
Westerhout, J.
Meima, M.Y.
Blom, W.M.
Kruizinga, A.G.
Wheeler, M.W.
Taylor, S.L.
Houben, G.F.
Baumert, J.L.
Publication year
2020
Abstract
Food allergy and allergen management are important global public health issues. In 2011, the first iteration of our allergen threshold database (ATDB) was established based on individual NOAELs and LOAELs from oral food challenge in roughly 1750 allergic individuals. Population minimal eliciting dose (EDp) distributions based on this dataset were published for 11 allergenic foods in 2014. Systematic data collection has continued (2011–2018) and the dataset now contains over 3400 data points. The current study provides new and updated EDp values for 14 allergenic foods and incorporates a newly developed Stacked Model Averaging statistical method for interval-censored data. ED01 and ED05 values, the doses at which 1%, and respectively 5%, of the respective allergic population would be predicted to experience any objective allergic reaction were determined. The 14 allergenic foods were cashew, celery, egg, fish, hazelnut, lupine, milk, mustard, peanut, sesame, shrimp (for crustacean shellfish), soy, walnut, and wheat. Updated ED01 estimates ranged between 0.03 mg for walnut protein and 26.2 mg for shrimp protein. ED05 estimates ranged between 0.4 mg for mustard protein and 280 mg for shrimp protein. The ED01 and ED05 values presented here are valuable in the risk assessment and subsequent risk management of allergenic foods. © 2020
Subject
Allergy
FoodLabeling
Model averaging
Risk assessment
Threshold
Allergic reaction
Analytical parameters
Cashew nut
Celery
Egg
Fish meal
Hazelnut
Lupin
Milk
Minimal eliciting dose distribution
Mustard
Peanut
Prediction
Risk assessment
Sesame
Shrimp
Soy food
Trend study
Walnut
Wheat
To reference this document use:
http://resolver.tudelft.nl/uuid:21a3d57f-bb55-4fd1-8430-db31c8b12a7e
DOI
https://doi.org/10.1016/j.fct.2020.111259
TNO identifier
875451
ISSN
0278-6915
Source
Food and Chemical Toxicology, 139
Article number
111259
Document type
article