Print Email Facebook Twitter Cost-effectiveness of newborn screening for cystic fibrosis determined with real-life data Title Cost-effectiveness of newborn screening for cystic fibrosis determined with real-life data Author van der Ploeg, C.P.B. van den Akker-van Marle, M.E. Vernooij-van Langen, A.M.M. Elvers, L.H. Gille, J.J.P. Verkerk, P.H. Dankert-Roelse, J.E. Loeber, J.G. Triepels, R.H. van der Pal, S.M. Dompeling, E. Pals, G. Gulmans, V.A.M. Oey-Spauwen, M.J.W. Wijnands, Y.H.H.M. Castricum, L.M. Arets, H.G.M. van der Ent, C.K. Tiddens, H.A.W.M. de Rijke, Y.B. Yntema, J.B. Publication year 2015 Abstract BACKGROUND: Previous cost-effectiveness studies using data from the literature showed that newborn screening for cystic fibrosis (NBSCF) is a good economic option with positive health effects and longer survival. METHODS: We used primary data to compare cost-effectiveness of four screening strategies for NBSCF, i.e. immunoreactive trypsinogen-testing followed by pancreatitis-associated protein-testing (IRT-PAP), IRT-DNA, IRT-DNA-sequencing, and IRT-PAP-DNA-sequencing, each compared to no-screening. A previously developed decision analysis model for NBSCF was fed with model parameters mainly based on a study evaluating two novel screening strategies among 145,499 newborns in The Netherlands. RESULTS: The four screening strategies had cost-effectiveness ratios varying from €23,600 to €29,200 per life-year gained. IRT-PAP had the most favourable cost-effectiveness ratio. Additional life-years can be gained by IRT-DNA but against higher costs. When treatment costs reduce with 5% due to early diagnosis, screening will lead to financial savings. CONCLUSION: NBSCF is as an economically justifiable public health initiative. Of the four strategies tested IRT-PAP is the most economic and this finding should be included in any decision making model, when considering implementation of newborn screening for CF Subject Behavioural ChangesCH - Child HealthELSS - Earth, Life and Social SciencesHealthy for LifeHealthHealthy LivingCystic fibrosisNewborn screeningCost-effectivenessCost-effectivenessNewborn screeningChildhood mortalityControlled studyCost effectiveness analysisCystic fibrosisDiagnostic test accuracy studyDNA sequenceEarly diagnosisGenetic counselingImmunoreactive trypsinogen DNAImmunoreactive trypsinogen DNA sequencingImmunoreactive trypsinogen pancreatitis associated protein DNA sequencingImmunoreactive trypsinogen pancreatitis associated protein testingMajor clinical studyNetherlandsNewbornNewborn diseaseNewborn screeningQuality adjusted life yearSensitivity analysisSensitivity and specificitySweat test To reference this document use: http://resolver.tudelft.nl/uuid:20b608bd-cc36-4a7c-977c-4ba39273d926 DOI https://doi.org/10.1016/j.jcf.2014.08.007 TNO identifier 516320 Source Journal of Cystic Fibrosis, 14 (2), 194-202 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.