Title
Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study
Author
Meulenbelt, I.
Bijkerk, C.
de Wildt, S.C.M.
Miedema, H.S.
Valkenburg, H.A.
Breedveld, F.C.
Pols, H.A.P.
TeKoppele, J.M.
Sloos, V.F.G.
Hofman, A.
Slagboom, P.E.
van Duijn, C.M.
Publication year
1997
Abstract
Objective. To investigate whether radiographically evident osteoarthritis (ROA) in 55-65-year-old men and women is associated with specific alleles or genotypes of the cartilage matrix protein (CRTM) and cartilage link protein (CRTL1) genes. Methods. Cases were selected from a population-based study on the presence of ROA of the knee or hip. Further radiographic analysis included scoring for spine and hand ROA. Controls, selected from the same population, were free of ROA in all joints. Results. The CRTM locus was significantly associated with hip ROA in men (odds ratio 0.50, 95% confidence interval 0.26-0.95). A significant association between ROA and the CRTL1 gene was not observed. Conclusion. These results suggest that the CRTM locus may play a role in the sex- and joint site-specific pattern of ROA development.
Subject
Biomedical Research
adult
allele
article
cartilage matrix
controlled study
coxitis
female
gene locus
genetic polymorphism
genetic predisposition
genetic variability
genotype
human
major clinical study
male
osteoarthritis
priority journal
Aged
Extracellular Matrix Proteins
Female
Genes
Glycoproteins
Hip Joint
Humans
Male
Middle Aged
Osteoarthritis
Proteins
Proteoglycans
Sex Characteristics
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DOI
https://doi.org/10.1002/art.1780401006
TNO identifier
160321
Source
Arthritis and rheumatism, 40 (40), 1760-1765
Document type
article