Title
Biodegradable Poly(ester) Urethane Acrylate Resins for Digital Light Processing: From Polymer Synthesis to 3D Printed Tissue Engineering Constructs
Author
Wang, R.
Damanik, F.
Kuhnt, T.
Jaminon, A.
Hafeez, S.
Liu, H.
Ippel, H.
Dijkstra, P.J.
Bouvy, N.
Schurgers, L.
ten Cate, A.T.
Dias, A.
Moroni, L.
Baker, M.B.
Publication year
2023
Abstract
Digital light processing (DLP) is an accurate and fast additive manufacturing technique to produce a variety of products, from patient-customized biomedical implants to consumer goods. However, DLP's use in tissue engineering has been hampered due to a lack of biodegradable resin development. Herein, a library of biodegradable poly(esters) capped with urethane acrylate (with variations in molecular weight) is investigated as the basis for DLP printable resins for tissue engineering. The synthesized oligomers show good printability and are capable of creating complex structures with mechanical moduli close to those of medium-soft tissues (1-3 MPa). While fabricated films from different molecular weight resins show few differences in surface topology, wettability, and protein adsorption, the adhesion and metabolic activity of NCTC clone 929 (L929) cells and human dermal fibroblasts (HDFs) are significantly different. Resins from higher molecular weight oligomers provide greater cell adhesion and metabolic activity. Furthermore, these materials show compatibility in a subcutaneous in vivo pig model. These customizable, biodegradable, and biocompatible resins show the importance of molecular tuning and open up new possibilities for the creation of biocompatible constructs for tissue engineering.
Subject
DLP printing
3D printing
Biocompatibility
Biodegradable polymers
Cell adhesion
Cell culture
Esters
Mammals
Metabolism
Molecular weight
Oligomers
Tissue engineering
Biofabrication
Digital light processing printing
Metabolic activity
Polies
Polyester
Polyesterurethanes
Polymer synthesis
Tissues engineerings
Urethane acrylate
Resins
To reference this document use:
http://resolver.tudelft.nl/uuid:207fd71e-ef74-4935-9abe-30b1eac9abaa
DOI
https://doi.org/10.1002/adhm.202202648
TNO identifier
982787
Publisher
John Wiley and Sons Inc
ISSN
2192-2640
Source
Advanced Healthcare Materials
Document type
article