Print Email Facebook Twitter Work stress and risk of cancer: Meta-analysis of 5700 incident cancer events in 116 000 European men and women Title Work stress and risk of cancer: Meta-analysis of 5700 incident cancer events in 116 000 European men and women Author Heikkila, K. Nyberg, S.T. Theorell, T. Fransson, E.I. Alfredsson, L. Bjorner, J.B. Bonenfant, S. Borritz, M. Bouillon, K. Burr, H. Dragano, N. Geuskens, G.A. Goldberg, M. Hamer, M. Hooftman, W.E. Houtman, I.L.D. Joensuu, M. Knutsson, A. Koskenvuo, M. Koskinen, A. Kouvonen, A. Madsen, I.E.H. Hanson, L.L.M. Marmot, M.G. Nielsen, M.L. Nordin, M. Oksanen, T. Pentti, J. Salo, P. Rugulies, R. Steptoe, A. Suominen, S. Vahtera, J. Virtanen, M. Vaaanen, A. Westerholm, P. Westerlund, H. Zins, M. Ferrie, J.E. Singh-Manoux, A. David, G. Kivimaki, M. Publication year 2013 Abstract Objective To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. Design Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116 056 men and women aged 17-70 who were free from cancer at study baseline and were followed-up for a median of 12 years. Work stress was measured and defined as job strain, which was self reported at baseline. Incident cancers (all n=5765, colorectal cancer n=522, lung cancer n=374, breast cancer n=1010, prostate cancer n=865) were ascertained from cancer, hospital admission, and death registers. Data were analysed in each study with Cox regression and the study specific estimates pooled in meta-analyses. Models were adjusted for age, sex, socioeconomic position, body mass index (BMI), smoking, and alcohol intake Results A harmonised measure of work stress, high job strain, was not associated with overall risk of cancer (hazard ratio 0.97, 95% confidence interval 0.90 to 1.04) in the multivariable adjusted analyses. Similarly, no association was observed between job strain and the risk of colorectal (1.16, 0.90 to 1.48), lung (1.17, 0.88 to 1.54), breast (0.97, 0.82 to 1.14), or prostate (0.86, 0.68 to 1.09) cancers. There was no clear evidence for an association between the categories of job strain and the risk of cancer. Conclusions These findings suggest that work related stress, measured and defined as job strain, at baseline is unlikely to be an important risk factor for colorectal, lung, breast, or prostate cancers. Subject OrganisationWH - Work & HealthBSS - Behavioural and Societal SciencesWork and EmploymentErgonomicsHealthy Living To reference this document use: http://resolver.tudelft.nl/uuid:1fd622f5-8147-4a25-b0f5-3bde05767253 DOI https://doi.org/10.1136/bmj.f165 TNO identifier 470339 ISSN 1756-1833 Source BMJ (Online), 346 (7896) Article number f165 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.