Title
Four-week oral toxicity study with erythritol in rats
Author
Til, H.P.
Modderman, J.
TNO Voeding
Publication year
1996
Abstract
Erythritol was orally administered to Wistar rats at dietary levels of 0, 5, and 10% for 4 weeks. Soft stools and diarrhea were observed in male and female animals of the 10% group and in female animals of the 5% group. These symptoms disappeared during the course of the study. Mean body weights of male rats in the high-dose group were significantly lower than those of controls during the course of the study. No such differences were observed in females. Small statistically significant changes in certain hematological, clinical chemistry, and urine parameters were noted in the high-dose group but were judged not to be biologically important. Weights of the cecum were increased relative to those of the controls. No treatment-related histological changes were observed. No ill effects, other than early diarrhea, were observed from erythritol levels at 5 or 10% in the diet. Based on these results, it was concluded that the feeding of erythritol at a dietary level of 10% did not result in toxicologically significant effects.
Subject
Toxicology
erythritol
animal experiment
article
body weight
cecum
controlled study
diarrhea
drug toxicity
female
histology
male
nonhuman
organ weight
priority journal
rat
Administration, Oral
Animals
Body Weight
Dose-Response Relationship, Drug
Drinking
Drug Administration Schedule
Eating
Erythritol
Female
Male
Organ Size
Potassium
Rats
Rats, Wistar
Sodium
Sweetening Agents
Animalia
Rattus norvegicus
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DOI
https://doi.org/10.1006/rtph.1996.0101
TNO identifier
233709
ISSN
0273-2300
Source
Regulatory Toxicology and Pharmacology, 24 (2 II)
Document type
article