Print Email Facebook Twitter Lack of inhibitory effects of beta-carotene, vitamin C, vitamin E and selenium on development of ductular adenocarcinomas in exocrine pancreas of hamsters Title Lack of inhibitory effects of beta-carotene, vitamin C, vitamin E and selenium on development of ductular adenocarcinomas in exocrine pancreas of hamsters Author Appel, M.J. van Garderen-Hoetmer, A. Woutersen, R.A. Instituut CIVO-Toxicologie en Voeding TNO Publication year 1996 Abstract The effects of vitamins E and E, β-carotene and selenium on development of N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic tumours in hamsters were investigated. Dietary supplementation of vitamin C, alone as well as in combination with β-carotene resulted in consistently lower numbers of advanced ductular lesions. The differences with the controls, however, did not reach the level of statistical significance. β-carotene alone demonstrated no inhibitory effect on the development of (pre)neoplastic lesions in the pancreas. Vitamin E or Se, either alone or in combination, had no effect on the development of advanced ductular lesions in BOP-treated hamsters. Chemicals/CAS: Ascorbic Acid, 50-81-7; beta Carotene, 7235-40-7; Carcinogens; Carotenoids, 36-88-4; Nitrosamines; nitrosobis(2-oxopropyl)amine, 60599-38-4; Selenium, 7782-49-2; Vitamin E, 1406-18-4 Subject NutritionAnimalsAscorbic Acidbeta CaroteneBody WeightCarcinogensCarcinoma, Ductal, BreastCarotenoidsCricetinaeDietMaleMesocricetusNitrosaminesOrgan SizePancreatic NeoplasmsSeleniumVitamin E To reference this document use: http://resolver.tudelft.nl/uuid:1c984bd9-8927-4ae3-80b9-4e5b1acdf4c2 DOI https://doi.org/10.1016/0304-3835(96)04207-3 TNO identifier 83679 Source Cancer Letters, 103 (2), 157-162 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.