Title
Lack of inhibitory effects of beta-carotene, vitamin C, vitamin E and selenium on development of ductular adenocarcinomas in exocrine pancreas of hamsters
Author
Appel, M.J.
van Garderen-Hoetmer, A.
Woutersen, R.A.
Instituut CIVO-Toxicologie en Voeding TNO
Publication year
1996
Abstract
The effects of vitamins E and E, β-carotene and selenium on development of N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic tumours in hamsters were investigated. Dietary supplementation of vitamin C, alone as well as in combination with β-carotene resulted in consistently lower numbers of advanced ductular lesions. The differences with the controls, however, did not reach the level of statistical significance. β-carotene alone demonstrated no inhibitory effect on the development of (pre)neoplastic lesions in the pancreas. Vitamin E or Se, either alone or in combination, had no effect on the development of advanced ductular lesions in BOP-treated hamsters. Chemicals/CAS: Ascorbic Acid, 50-81-7; beta Carotene, 7235-40-7; Carcinogens; Carotenoids, 36-88-4; Nitrosamines; nitrosobis(2-oxopropyl)amine, 60599-38-4; Selenium, 7782-49-2; Vitamin E, 1406-18-4
Subject
Nutrition
Animals
Ascorbic Acid
beta Carotene
Body Weight
Carcinogens
Carcinoma, Ductal, Breast
Carotenoids
Cricetinae
Diet
Male
Mesocricetus
Nitrosamines
Organ Size
Pancreatic Neoplasms
Selenium
Vitamin E
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DOI
https://doi.org/10.1016/0304-3835(96)04207-3
TNO identifier
83679
Source
Cancer Letters, 103 (2), 157-162
Document type
article