Title
Embryotoxicity and teratogenicity study with γ-cyclodextrin in rats
Author
Waalkens-Berendsen, D.H.
Verhagen, F.J.J.
Bär, A.
Publication year
1998
Abstract
The embryotoxicity/teratogenicity of γ-cyclodextrin (γ-CD) was examined in Wistar Crl:(WI)WU BR rats. γ-CD was fed at dietary concentrations of 0, 1.5, 5, 10, and 20% to groups of 25 pregnant female rats from day 0 to 21 of gestation. A comparison group received a diet with 20% lactose. The additions to the diet of γ-CD and lactose were made at the expense of pregelatinized potato starch. Body weight and food and water intake were recorded during the treatment period. The rats were killed on day 21 and examined for standard parameters of reproductive performance. The fetuses were examined for signs of toxic and teratogenic effects. Generally, γ-CD was well tolerated and no deaths occurred in any group. Weight gain and food consumption were similar in all groups during gestation, except for a slightly reduced food intake in the 20% γ-CD group from day 0 to 16. Water intake was similar in all γ-CD groups; in the lactose group, it was significantly higher than in the control group. Reproductive performance was not affected by the γ-CD treatment. Examination of the fetuses for external, visceral, and skeletal alterations did not reveal any fetotoxic, embryotoxic, or teratogenic effects of γ-CD. In conclusion, no adverse effects were observed at γ-CD intakes of up to about 20% of the diet (approximately 11 g/kg body wt/day). Chemicals/CAS: Cyclodextrins; gamma-cyclodextrin, 17465-86-0; gamma-Cyclodextrins; Teratogens
Subject
Biology
gamma cyclodextrin
lactose
animal experiment
animal tissue
article
body weight
controlled study
dose response
embryotoxicity
female
fetus
fetus weight
fluid intake
food intake
male
nonhuman
oral drug administration
priority journal
rat
sexual behavior
teratogenicity
uterus weight
Animal Feed
Animals
Body Weight
Cyclodextrins
Drinking
Eating
Female
Fetal Viability
Fetus
gamma-Cyclodextrins
Gestational Age
Male
Pregnancy
Rats
Rats, Wistar
Teratogens
Weight Gain
Animalia
Solanum tuberosum
To reference this document use:
http://resolver.tudelft.nl/uuid:1b837d02-cd0f-48a2-a6f5-0de725cee1c5
DOI
https://doi.org/10.1006/rtph.1998.1221
TNO identifier
234418
ISSN
0273-2300
Source
Regulatory Toxicology and Pharmacology, 27 (2), 166-171
Document type
article