Title
The proteomic toolbox for studying cerebrospinal fluid
Author
van Gool, A.J.
Hendrickson, R.C.
Publication year
2012
Abstract
Cerebrospinal fluid (CSF) can be considered the most promising biosample for the discovery and analysis of biomarkers in neuroscience, an area of great medical need. CSF is a body fluid that surrounds the brain and provides a rich pool of biochemical markers, both proteomic and metabolomic, that reflect the state of neurological processes. Such biomarkers can either serve as diagnostic or prognostic biomarkers to improve the characterization of patients and preclinical disease models, or can be used to demonstrate drug-related exposure and efficacy. Here, we describe the proteomic toolbox for studying CSF from a drug-discovery perspective, and the trends and challenges that lie ahead. © 2012 Expert Reviews Ltd.
Subject
Life
MHR - Metabolic Health Research
EELS - Earth, Environmental and Life Sciences
Healthy for Life
Healthy Living
biomarkers
CSF
drug development
proteomics
translational medicine
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http://resolver.tudelft.nl/uuid:1b5956a4-4811-415d-a593-0d8cd7cd4b55
DOI
https://doi.org/10.1586/epr.12.6
TNO identifier
452790
ISSN
1478-9450
Source
Expert Review of Proteomics, 9 (2), 165-179
Document type
article