Title
Dietary fish oil (MaxEPA) enhances pancreatic carcinogenesis in azaserine-treated rats
Author
Instituut CIVO-Toxicologie en Voeding TNO
Appel, M.J.
Woutersen, R.A.
Publication year
1996
Abstract
In the present study the putative chemopreventive effect of dietary fish oil (MaxEPA) on azaserine-induced pancreatic carcinogenesis in rats was investigated. Groups of rats were maintained on a semipurified low-fat (LF; 5 wt%) diet or on semipurified high-fat (HF; 25 wt%) diets containing 5 wt% linoleic acid (LA) and including 0.0, 1.2, 2.4, 4.7, 7.1 or 9.4 wt% MaxEPA. Animals fed a HF diet developed significantly higher mean numbers of atypical acinar cell nodules (AACNs), adenomas and carcinomas than animals fed a LF diet. Dietary MaxEPA caused a significant (P
Subject
Animals
Anticarcinogenic Agents
Azaserine
Body Weight
Carcinogens
Cell Division
Cocarcinogenesis
Dietary Fats, Unsaturated
Docosahexaenoic Acids
Drug Combinations
Drug Synergism
Eating
Eicosapentaenoic Acid
Fatty Acids
Fatty Acids, Omega-3
Female
Fish Oils
Liver
Organ Size
Pancreatic Neoplasms
Precancerous Conditions
Pregnancy
Prostaglandins
Rats
Rats, Wistar
To reference this document use:
http://resolver.tudelft.nl/uuid:1af80ae7-2a94-41cd-9ff5-7b824868ecb2
TNO identifier
69541
ISSN
0007-0920
Source
British Journal of Cancer, 73 (73), 36-43
Document type
article